ArticlebioRxiv : the preprint server for biology2025
Disease-causing mutations in the G protein β5 β-propeller disrupt its chaperonin-mediated folding trajectory.
Mikaila I Sass, Deirdre C Mack, Riley A Nickles, Caelen A Jones, Rex L Brunsdale, Samuel L Cottam, Peter S Shen, Barry M Willardson
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Mikaila I SassDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
Deirdre C MackDepartment of Biochemistry, School of Medicine, University of Utah, 15 N. Medical Drive East, Salt Lake City, UT 84112, USA.
Riley A NicklesDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
Caelen A JonesDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
Rex L BrunsdaleDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
Samuel L CottamDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.
Peter S ShenDepartment of Biochemistry, School of Medicine, University of Utah, 15 N. Medical Drive East, Salt Lake City, UT 84112, USA.ORCID 0000-0002-6256-6910 Barry M WillardsonDepartment of Chemistry and Biochemistry, Brigham Young University, C100 BNSN, Provo, UT 84602, USA.ORCID 0000-0002-8503-2268 Funding
Structural basis for chaperone-dependent folding of beta-propeller proteins essential for visionR01EY012287 · NEI · BRIGHAM YOUNG UNIVERSITY · PI WILLARDSON, BARRY M · 1999 to 2022
$5.7MVisualizing the Mechanisms of Protein Quality ControlR35GM133772 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Peter Shen · 2019 to 2026
$3.4MMechanisms of chaperone-mediated folding of beta-propeller proteins essential for vision.R01EY036925 · NEI · BRIGHAM YOUNG UNIVERSITY · PI Peter Shen, BARRY M WILLARDSON · 2025 to 2026
$923kMechanism of Substrate Unfolding by the AAA+ ATPase p97 and Binding PartnersF31GM150221 · NIGMS · UNIVERSITY OF UTAH · PI MACK, DEIRDRE · 2023 to 2024
$97kNEI NIH HHS R01 EY012287NEI NIH HHS R01 EY036925NIGMS NIH HHS F31 GM150221NIGMS NIH HHS R35 GM133772
6 · The paper itselfAbstract
The Chaperonin Containing Tailless polypeptide 1 (CCT or TRiC) is an essential cytosolic chaperone that folds multiple protein substrates, including many with β-propeller folds. One β-propeller substrate is the G protein β
Indexed as
chaperonincryo-electron microscopyG proteinmissense mutationsprotein folding
Identifiers
PMID40501749
PMCPMC12154622
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