ArticlebioRxiv : the preprint server for biology2025
Relative Timescale of Channel Voltage-Dependence and Channel Density Regulation Impacts Assembly and Recovery of Activity.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neurons can maintain stable activity profiles over their lifetimes despite ion channel turnover over minutes to weeks. Neuronal activity is also influenced by regulating the voltage-dependence of ion channels. How do these two forms of plasticity work together to maintain a stable activity profile? We augment a classical model of activity-dependent ion channel density regulation with a mechanism that adjusts channel voltage-dependence based on activity. These findings reveal that the timescale of these mechanisms shape the specific electrical activity patterns that achieve a target activity profile. Moreover, alterations in channel voltage-dependence can impact a neuron's ability to recover from perturbations. These results highlight a potentially distinct role for activity-dependent regulation of channel voltage-dependence in maintaining stable neuronal activity profiles.
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