Evidence map›Paper›PMID 40501742›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular dissection of Class A PBP function uncovers novel features of the non-canonical

Gregory A Harrison, Aimee Shen

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Gregory A HarrisonDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-6050-1312
Aimee ShenDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.ORCID 0000-0002-9786-5742

Funding

Tufts IRACDAK12GM133314 · NIGMS · TUFTS UNIVERSITY BOSTON · PI CLAIRE L MOORE, Jamie Lynn Maguire · 2019 to 2026
$8.4M
Spore Assembly in Clostridium DifficileR01AI122232 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SHEN, AIMEE · 2016 to 2025
$4.2M
Cell Division in ClostridioidesdifficileR37AI122232 · NIAID · TUFTS UNIVERSITY BOSTON · PI Aimee Shen · 2026 to 2026
$509k
NIAID NIH HHS R01 AI122232NIAID NIH HHS R37 AI122232NIGMS NIH HHS K12 GM133314
6 · The paper itself

Abstract

Cell division in bacteria is mediated by the "divisome," a multiprotein complex that synthesizes the septal peptidoglycan needed to divide one cell into two. We recently showed that the major nosocomial pathogen

Identifiers

PMID40501742
PMCPMC12154710

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.