Evidence map›Paper›PMID 40501735›Full record

ArticlebioRxiv : the preprint server for biology2025

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia.

Gandhar K Datar, Elmira Khabusheva, Archish Anand, Joshua Beale, Marwa Sadek, Chun-Wei Chen, Evdokiia Potolitsyna, Nayara Alcantara-Contessoto, Guangyuan Liu, Josephine De La Fuente and 15 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Gandhar K DatarMedical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8982-1475
Elmira KhabushevaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Archish AnandDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Joshua BealeDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Marwa SadekDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Chun-Wei ChenDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Evdokiia PotolitsynaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Nayara Alcantara-ContessotoDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Guangyuan LiuDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Josephine De La FuenteDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Christina DollingerDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Anna GuzmanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Alejandra MartellDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Katharina WohlanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Abhishek MaitiDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nicholas J ShortDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
S Stephen YiBaylor Research Institute and Baylor College of Medicine, Temple, TX, USA.
Vibeke AndresenK.G. Jebsen Centre for Myeloid Blood Cancer, Department of Clinical Science, University of Bergen, Bergen, Norway.
Bjørn Tore GjertsenK.G. Jebsen Centre for Myeloid Blood Cancer, Department of Clinical Science, University of Bergen, Bergen, Norway.
Brunangelo FaliniInstitute of Hematology and Center for Hemato-Oncological research (CREO), University of Perugia and Santa Maria della Misericordia Hospital, Perugia, Italy.
Rachel E RauBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
Lorenzo BrunettiDepartment of Molecular and Clinical Sciences, Università Politecnica delle Marche, Ancona, Italy.
Nidhi SahniDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Margaret A GoodellMedical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0003-1111-2932
Joshua A RibackDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-1516-4484

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAMK12CA090433 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CARL E ALLEN, Donald W. Parsons · 2002 to 2026
$18.5M
DNMT3A in Development of Hematologic MalignanciesR01CA183252 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL · 2014 to 2026
$7.1M
DEFINING THE ROLE OF DOT1L IN DNMT3A-MUTANT LEUKEMIAK08CA201611 · NCI · BAYLOR COLLEGE OF MEDICINE · PI RAU, RACHEL E · 2017 to 2019
$486k
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Defining the Synergistic Role of NPM1 and DNMT3A Mutations on HOX Gene Regulation in the Pathogenesis of Acute Myeloid LeukemiaF30CA268725 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DATAR, GANDHAR KIRAN · 2022 to 2023
$98k
NCI NIH HHS F30 CA268725NCI NIH HHS K08 CA201611NCI NIH HHS K12 CA090433NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA183252NCRR NIH HHS S10 RR024574
6 · The paper itself

Abstract

During cancer development, mutations promote gene expression changes that cause transformation. Leukemia is frequently associated with aberrant

Identifiers

PMID40501735
PMCPMC12154763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.