ArticlebioRxiv : the preprint server for biology2025
Chondrocyte-Specific Knockout of
Erica V Ely, Kristin L Lenz, Sophie G Paradi, Seth Ack, Abraham Behrmann, Sarah Dunivan, Lauryn Braxton, Wolfgang Liedtke, Yong Chen, Kelsey H Collins and 1 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors.
Erica V ElyDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Kristin L LenzDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Sophie G ParadiDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Seth AckDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Abraham BehrmannDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Sarah DunivanDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Lauryn BraxtonDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.
Yong ChenDepartment of Neurology, Duke University, Durham, North Carolina.
Kelsey H CollinsDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.ORCID 0000-0001-7348-7348 Farshid GuilakDepartment of Orthopaedic Surgery, Washington University in Saint Louis, Saint Louis, Missouri.ORCID 0000-0001-7380-0330 Funding
VISCOELASTIC PROPERTIES OF NORMAL AND OA CHONDRONSR01AG015768 · NIA · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 1998 to 2022
$7.7MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MGenetically-engineered stem cells for self-regulating arthritis therapyR01AR080902 · NIAMS · WASHINGTON UNIVERSITY · PI Farshid Guilak, Christine T. Pham · 2022 to 2026
$3.7MOBESITY, BIOMECHANICS, AND INFLAMMATION IN OSTEOARTHRITISR01AG046927 · NIA · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 2013 to 2023
$3.2MDeconstructing Cartilage Mechanotransduction by Piezo ChannelsR01AR072999 · NIAMS · WASHINGTON UNIVERSITY · PI GUILAK, FARSHID · 2020 to 2024
$2.9MThe Role of Fat in OsteoarthritisR00AR078949 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLINS, KELSEY HELEN-MARIE · 2023 to 2025
$715kThe Multiscale Role of Piezo Channels in Obesity-Associated Cartilage DamageF31AR079260 · NIAMS · WASHINGTON UNIVERSITY · PI ELY, ERICA VALENTINE · 2022 to 2025
$192kNIAMS NIH HHS F31 AR079260NIAMS NIH HHS P30 AR073752NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R00 AR078949NIAMS NIH HHS R01 AR072999NIAMS NIH HHS R01 AR080902NIA NIH HHS R01 AG015768NIA NIH HHS R01 AG046927
6 · The paper itselfAbstract
Background: Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the underlying pathophysiology. Mechanosensitive ion channels Piezo1 and Piezo2 play crucial roles in chondrocyte responses to mechanical stress, mediating mechanotransduction pathways that influence chondrocyte survival, matrix production, and inflammatory signaling, but their distinct contributions to OA pathogenesis remain unclear. Methods: Using inducible, chondrocyte-specific Aggrecan-Cre ( Results: Conclusions: These findings demonstrate the overlapping and compensatory roles of
Indexed as
DMOADsMechanosensitive Ion ChannelsMechanotransductionMeniscusPain ModulationSubchondral bone
Identifiers
PMID40501713
PMCPMC12154791
What OpenQuestion holds
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