Evidence map›Paper›PMID 40501709›Full record

ArticlebioRxiv : the preprint server for biology2025

Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.

Adrien Grimont, David J Falvo, Whitney J Sisso, Paul Zumbo, Christopher W Chan, Francisco Santos, Grace Pan, Megan Cleveland, Tomer M Yaron, Alexa Osterhoudt and 12 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Adrien Grimont
David J Falvo
Whitney J Sisso
Paul Zumbo
Christopher W Chan
Francisco Santos
Grace Pan
Megan Cleveland
Tomer M Yaron
Alexa Osterhoudt
Yinuo Meng
Maria Paz Zafra
William B Fall
Erika Hissong
Rhonda K Yantiss
Steven D Leach
Anil K Rustgi

Funding

Defining the molecular determinants of inflammatory memory in the pancreasR01DK138154 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rohit Chandwani · 2024 to 2026
$1.5M
Defining the oncogenic potential and therapeutic dependencies of PDAC-associated KRAS variantsR01CA290616 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rohit Chandwani, LUKAS Edward DOW · 2025 to 2026
$1.3M
Understanding Kras Mutation Heterogeneity in PDACF31CA288132 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Whitney Juliet Sisso · 2024 to 2026
$149k
NCI NIH HHS F31 CA288132NCI NIH HHS R01 CA290616NIDDK NIH HHS R01 DK138154
6 · The paper itself

Abstract

Inflammation in the pancreas drives acinar-to-ductal metaplasia (ADM), a progenitor-like state that can be hijacked by mutant SIGNIFICANCE: Defining how

Identifiers

PMID40501709
PMCPMC12154683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.