Evidence map›Paper›PMID 40501703›Full record

ArticlebioRxiv : the preprint server for biology2025

Autism-associated

Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, Morgan J Robinson, Harish Kothandaraman, Ye-Eun Yoo, Iria M Gonzalez Dopeso-Reyes, Thomas D Buffenoir, Manasi S Halurkar, Zaiyang Zhang and 13 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel advanced patient-derivedFrontiers in neurology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Xiaoling ChenBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Jingliang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-2903-1287
Jiaxiang WuBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Morgan J RobinsonBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Harish KothandaramanPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Ye-Eun YooBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Iria M Gonzalez Dopeso-ReyesInstitut de Génétique Moléculaire de Montpellier, CNRS, and Université de Montpellier, Montpellier, France.ORCID 0000-0003-1866-6305
Thomas D BuffenoirInstitut de Génétique Moléculaire de Montpellier, CNRS, and Université de Montpellier, Montpellier, France.
Manasi S HalurkarBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Zaiyang ZhangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Muhan WangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Erin N CreagerCollege of Science, Purdue University, West Lafayette, IN 47907, USA.
Yuanrui ZhaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Maria I Olivero-AcostaBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Kyle W WettschurackBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Zhefu QueBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
Chongli YuanPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Allison J SchaserPurdue Institute for Integrative Neuroscience, Purdue University, West Lafayette, IN 47907, USA.
Nadia A LanmanPurdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Jean-Christophe RochetBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.
William C SkarnesThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Eric J KremerInstitut de Génétique Moléculaire de Montpellier, CNRS, and Université de Montpellier, Montpellier, France.
Yang YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-6417-3654

Funding

Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Neuronal and Behavioral Deficits Associated with Scn2a Deficiency in Autism Spectrum DisorderR01NS117585 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$2.0M
Neuronal hyperexcitability and seizures in a Scn2a deficient mouse modelR01NS123154 · NINDS · PURDUE UNIVERSITY · PI YANG, YANG · 2021 to 2025
$1.9M
NCI NIH HHS P30 CA023168NCI NIH HHS P30 CA082709NINDS NIH HHS R01 NS117585NINDS NIH HHS R01 NS123154
6 · The paper itself

Abstract

Profound autism spectrum disorder (ASD) is frequently attributable to single-gene mutations, with

Indexed as

assembloidautismbrain organoidcortico-striatal circuitlive-cell imagingNaV1.2SCN2A-C959X

Identifiers

PMID40501703
PMCPMC12157400

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.