Evidence map›Paper›PMID 40501702›Full record

ArticlebioRxiv : the preprint server for biology2025

Harnessing Microbial Tools:

Elizabeth M DiLoreto, Shruti Shastry, Emily J Leptich, Douglas K Reilly, Rachel N Arey, Jagan Srinivasan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Elizabeth M DiLoreto
Shruti Shastry
Emily J Leptich

Funding

Uncovering brain-wide molecular determinants of individual memory performance across lifespanDP2NS132372 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI AREY, RACHEL NICOLE · 2022 to 2025
$2.4M
Investigating neuropeptide signals that slow cognitive aging in C. elegansF31AG081095 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LEPTICH, EMILY JEAN · 2023 to 2024
$97k
NIA NIH HHS F31 AG081095NINDS NIH HHS DP2 NS132372
6 · The paper itself

Abstract

Animals respond to changes in their environment and internal states via neuromodulation. Neuropeptides modulate neural circuits with flexibility because one gene can produce either multiple copies of the same neuropeptide or different neuropeptides. However, with this architectural complexity, the function of discrete and active neuropeptides is muddled. Here, we design a genetic tool that facilitates functional analysis of individual peptides. We engineered Article summary: Studying individual neuropeptides opens new avenues for exploring neuromodulation at a finer resolution. The researchers developed a method to create DNA vectors that encode an endogenous peptide sequence flanked by sequences containing dibasic endopeptidase cleavage sites in

Identifiers

PMID40501702
PMCPMC12154602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.