Evidence map›Paper›PMID 40501678›Full record

ArticlebioRxiv : the preprint server for biology2025

Female cortical cellular mosaicism underlies shared MeCP2 and PCB impacted gene pathways.

Osman Sharifi, Kari E Neier, Anthony Valenzuela, Christina G Torres, Ian Korf, Pamela J Lein, Dag H Yasui, Janine M LaSalle

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Osman SharifiMedical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616.
Kari E NeierMedical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616.
Anthony ValenzuelaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616.
Christina G TorresMedical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616.
Ian KorfCellular and Molecular Biology, College of Biological Sciences, University of California, Davis, CA 95616.
Pamela J LeinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616.
Dag H YasuiMedical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616.
Janine M LaSalleMedical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616.

Funding

UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
West Coast Central Comprehensive Metabolomics Resource Core (WC3MRC)U24DK097154 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2012 to 2017
$9.9M
ENVIRONMENTAL TOXICOLOGYT32ES007059 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI Laura S Van Winkle · 1985 to 2026
$7.9M
PCB Epigenomic Brain & Behavior Lasting Effects Study (PEBBLES)R01ES029213 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Janine M LaSalle, Pamela J Lein · 2018 to 2026
$6.5M
West Coast Metabolomics Center for Compound IdentificationU2CES030158 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FIEHN, OLIVER · 2018 to 2021
$4.1M
Neuroimmune interactions in Rett syndromeR01AA027075 · NIAAA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LASALLE, JANINE M · 2018 to 2022
$2.9M
Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencinS10OD010786 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COMAI, LUCA · 2012 to 2012
$311k
NIAAA NIH HHS R01 AA027075NIDDK NIH HHS U24 DK097154NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES029213NIEHS NIH HHS T32 ES007059NIEHS NIH HHS U2C ES030158NIH HHS S10 OD010786
6 · The paper itself

Abstract

Etiologies of neurodevelopmental disorders involve genes and environment however their interactions are understudied. Rett Syndrome (RTT) is an X-linked, dominant neurodevelopmental disorder caused by mutations in

Indexed as

autism spectrum disordersepigeneticsneurodevelopmental disorderspersistent organic pollutantspolychlorinated biphenylsRett syndromesystems biologyX chromosome inactivation

Identifiers

PMID40501678
PMCPMC12154872

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.