Evidence map›Paper›PMID 40501655›Full record

ArticlebioRxiv : the preprint server for biology2025

Bacterial peptide deformylase inhibitors induce prophages in competitors.

Julie Chen, Katarina Pfeifer, Kerrin Steensen, Anne Marie Crooke, Michael Wolfram, Jacob Bobonis, Anna Lopatina, Nina Bartlau, Fatima A Hussain, Emily P Balskus and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Julie ChenMicrobiology Graduate Program, Massachusetts Institute of Technology; Cambridge, MA 02139, United States.ORCID 0000-0003-4648-7478
Katarina PfeiferDepartment of Chemistry and Chemical Biology, Harvard University; Cambridge, MA 02138, United States.ORCID 0000-0001-9671-1234
Kerrin SteensenCentre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna; Djerassiplatz 1, 1030 Vienna, Austria.ORCID 0009-0007-3937-0550
Anne Marie CrookeDepartment of Chemistry and Chemical Biology, Harvard University; Cambridge, MA 02138, United States.ORCID 0000-0002-1581-6104
Michael WolframCentre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna; Djerassiplatz 1, 1030 Vienna, Austria.ORCID 0009-0009-7021-3566
Jacob BobonisCentre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna; Djerassiplatz 1, 1030 Vienna, Austria.ORCID 0000-0001-9293-9733
Anna LopatinaCentre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna; Djerassiplatz 1, 1030 Vienna, Austria.ORCID 0000-0002-3484-6819
Nina BartlauCentre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna; Djerassiplatz 1, 1030 Vienna, Austria.
Fatima A HussainDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology; Cambridge, MA 02139, USA.ORCID 0000-0001-8926-3875
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University; Cambridge, MA 02138, United States.ORCID 0000-0001-5985-5714
Martin F PolzCentre for Microbiology and Environmental Systems Science, Division of Microbial Ecology, University of Vienna; Djerassiplatz 1, 1030 Vienna, Austria.ORCID 0000-0002-4975-2946
Paul C BlaineyBroad Institute of MIT and Harvard; Cambridge, MA 02142, United States.ORCID 0000-0002-4889-8783

Funding

The biosynthesis of N-N bond-containing natural productsR01GM132564 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM132564
6 · The paper itself

Abstract

While antibiotics mediate chemical warfare among microbes, their roles in the wild extend beyond direct growth inhibition(1). Some antibiotics have the potential to mediate interference competition by triggering a bacterial stress response that subsequently activates endogenous viruses integrated in bacterial genomes (prophages). Canonically, this activation is regulated by the SOS response upon DNA damage. Here we show that a metabolite produced by natural isolates of

Identifiers

PMID40501655
PMCPMC12157366

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.