Evidence map›Paper›PMID 40501653›Full record

ArticlebioRxiv : the preprint server for biology2025

Adaptive-like NK cell responses to influenza correlate with humoral immunity and are influenced by age and sex.

Eric Alves, Jared M Oakes, Joshua D Simmons, Jennifer Currenti, Jerome D Coudert, Bree Foley, Joan Eason, Natasha B Halasa, H Keipp Talbot, Jessica L Castilho and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Eric AlvesSchool of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0002-6072-708X
Jared M OakesDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-3910-1346
Joshua D SimmonsDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Jennifer CurrentiCurtin Medical School, Curtin Health Research Institute, Curtin University, Bentley, Western Australia, Australia.ORCID 0000-0003-4609-587X
Jerome D CoudertMurdoch University, Personalised Medicine Center, Murdoch, Western Australia, Australia.ORCID 0000-0001-6081-8494
Bree FoleySchool of Biomedical Sciences, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0003-3826-2682
Joan EasonDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Natasha B HalasaDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
H Keipp TalbotDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0141-1760
Jessica L CastilhoDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Simon A MallalDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-7036-1309
Silvana GaudieriSchool of Human Sciences, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0001-6873-0198
Spyros A KalamsDepartment of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-0098-7995

Funding

Single cell molecular analysis of influenza vaccine responses in elderly individualsR01AI142095 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KALAMS, SPYROS A · 2019 to 2023
$2.9M
NIAID NIH HHS R01 AI142095
6 · The paper itself

Abstract

Influenza remains a global health threat, infecting approximately one billion people annually and causing significant mortality, particularly among older adults. While hemagglutination inhibition (HAI) antibody titers are a standard correlate of immunity against influenza, they do not reliably predict protection in high-risk populations. Using multiomic single-cell profiling, we identified a distinct subset of adaptive-like NK cells that respond to influenza antigen, predominantly in younger females. These

Indexed as

AgingInfluenzaKiller Immunoglobulin-like ReceptorsMemoryNK cellsSingle cellVaccination

Identifiers

PMID40501653
PMCPMC12154681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.