Evidence map›Paper›PMID 40501652›Full record

ArticlebioRxiv : the preprint server for biology2025

A new heme enzyme family forms hydrazine groups in diverse biosynthetic pathways.

Grace E Kenney, Kwo-Kwang A Wang, Tai L Ng, Wilfred A van der Donk, Emily P Balskus

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Grace E KenneyDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge 02138 MA, USA.ORCID 0000-0002-9579-3351
Kwo-Kwang A WangDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana 61801 IL, USA.ORCID 0000-0003-0564-4019
Tai L NgDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge 02138 MA, USA.ORCID 0000-0003-1763-5590
Wilfred A van der DonkDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana 61801 IL, USA.ORCID 0000-0002-5467-7071
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge 02138 MA, USA.ORCID 0000-0001-5985-5714

Funding

Structural Elucidation and Biosynthesis P01GM077596 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI METCALF, WILLIAM W · 2007 to 2016
$15.3M
The biosynthesis of N-N bond-containing natural productsR01GM132564 · NIGMS · HARVARD UNIVERSITY · PI BALSKUS, EMILY PATRICIA · 2020 to 2023
$1.5M
NIGMS NIH HHS P01 GM077596NIGMS NIH HHS R01 GM132564
6 · The paper itself

Abstract

Nitrogen-nitrogen (N-N) bond formation is an inherently challenging chemical process that plays a key role in the global nitrogen cycle. An array of microbial metalloenzyme complexes has evolved to shuttle nitrogen between biologically accessible reduced or oxidized states and its inert form as dinitrogen (N

Identifiers

PMID40501652
PMCPMC12154649

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.