Evidence map›Paper›PMID 40501649›Full record

ArticlebioRxiv : the preprint server for biology2025

A lineage-specific heat-induced feedback loop controls HrcA to promote chlamydial fitness under stress.

Yehong Huang, Yuxuan Wang, Matthew Pan, Danny Wan, Lingling Wang, Joseph D Fondell, Xiang Wu, Guangming Zhong, Huizhou Fan

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yehong HuangDepartment of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.ORCID 0000-0001-8186-1088
Yuxuan WangDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0003-0771-1078
Matthew PanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-1043-3681
Danny WanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0001-8262-8173
Lingling WangDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
Joseph D FondellDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-7046-9854
Xiang WuDepartment of Parasitology, Central South University Xiangya Medical School, Changsha, Hunan 410078, China.ORCID 0000-0001-9013-742X
Guangming ZhongDepartment of Microbiology and Immunology, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-7053-5009
Huizhou FanDepartment of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-4903-926X

Funding

An oral vaccine against Chlamydia trachomatisU01AI182210 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUANGMING ZHONG · 2024 to 2026
$6.5M
GrgA:a Multifunctional Transcription Factor that Control Chlamydial Gene ExpressionR21AI140167 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2019 to 2020
$435k
Exploration of SF3 as a Chemical Probe for Chlamydial BiologyR21AI154305 · NIAID · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI FAN, HUIZHOU · 2020 to 2021
$431k
NIAID NIH HHS R21 AI140167NIAID NIH HHS R21 AI154305NIAID NIH HHS U01 AI182210
6 · The paper itself

Abstract

Bacterial stress responses rely on transcriptional regulation by sigma factors and repressors. In

Indexed as

chaperoneChlamydiaCT016CTL0271DnaKGroESLHagFheat shock responseHrcAstress response

Identifiers

PMID40501649
PMCPMC12154930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.