ArticlebioRxiv : the preprint server for biology2025
Dynamic Magnetic Resonance Imaging of Whole-Stomach Motility in Rats.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Understanding gastric physiology in rodents is critical for advancing preclinical neurogastroenterology research. However, existing techniques are often invasive, terminal, or limited in resolution. This study aims to develop a non-invasive, standardized MRI protocol capable of capturing whole-stomach dynamics in anesthetized rats with high spatiotemporal resolution. Methods: Experiments were performed in a 7-Tesla MRI system. Gadolinium-doped test meals were prepared to enhance intraluminal contrast in T Results: The protocol enabled successful imaging of the stomach and visualization of its pseudo-periodic dynamics in anesthetized rats. The gadolinium-doped meal produced relatively homogeneous intraluminal contrast, allowing clear delineation of gastric anatomy, volume, and motility. The retrospectively reconstructed image exhibited high image quality and yielded reliable estimates of antral contractions, confirming the effectiveness and robustness of k-t interpolation method. Estimated antral contraction amplitude and velocity showed minimal deviations from the reference values, whereas contraction frequency estimation remained highly consistent and accurate. Prospective acquisitions using the accelerated imaging protocol successfully imaged the entire stomach and major intestinal regions, acquiring 24 slices every < 3 s and capturing antral contraction at ∼5 cycles per minute. Conclusion: We established an accessible and standardized imaging protocol that encompasses contrast meal preparation, animal handling and training, and a contrast-enhanced dynamic GI MRI acquisition and reconstruction framework. Significance: This protocol provides a comprehensive, robust, non-invasive tool for studying gastric motility and dysmotility in rodents, offering strong potential to advance preclinical gastrointestinal motility research. Graphic Abstract: In this paper, we report a standardized, non-invasive imaging protocol that encompasses animal handling and training, contrast meal preparation, and a contrast-enhanced dynamic GI MRI acquisition and reconstruction framework for imaging whole-stomach dynamics in anesthetized rats.
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