ArticlebioRxiv : the preprint server for biology2025
The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of
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Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
27 authors.
Fangfei JiangDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Michael BoylanDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Dale W MaxwellDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Wasay Mohiuddin Shaikh QureshiDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Charlie F RowlandsDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Gennadiy TeninDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.ORCID 0000-0002-1600-4124
Karen MitchellDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Louise A StephenDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Elton J R VasconcelosLeedsOmics, University of Leeds, Leeds, LS2 9JT, UK.
Dapeng WangLeedsOmics, University of Leeds, Leeds, LS2 9JT, UK.ORCID 0000-0002-9925-4574
Tong ChenDivision of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Junzhe ZhaDivision of Cell Matrix Biology and Regenerative Medicine, Manchester Cell-Matrix Centre, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Jingshu LiuDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Nouf AlthaliDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.ORCID 0000-0002-9141-8909
Dragos V LeordeanDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Meurig T GallagherCentre for Systems Modelling and Quantitative Biomedicine, University of Birmingham, Edgbaston, Birmingham, UK and Centre for Human Reproductive Science, University of Birmingham, Birmingham, UK.ORCID 0000-0002-6512-4472
Basudha BasuDivision of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, LS9 7TF, UK.
Katarzyna SzymanskaDivision of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, LS9 7TF, UK.
Advait VeeraghantaInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Drive, Singapore 138673, Singapore.
Bernard KeavneyDivision of Cardiovascular Sciences, BHF Manchester Centre of Research Excellence, School of Medical Sciences, Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, M13 9PL, UK.
Martin J HumphriesDivision of Cell Matrix Biology and Regenerative Medicine, Manchester Cell-Matrix Centre, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Jamie EllingfordDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
David SmithCentre for Systems Modelling and Quantitative Biomedicine, University of Birmingham, Edgbaston, Birmingham, UK and Centre for Human Reproductive Science, University of Birmingham, Birmingham, UK.
Colin A JohnsonDivision of Molecular Medicine, Leeds Institute of Medical Research, University of Leeds, Leeds, LS9 7TF, UK.
Raymond T O'KeefeDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.
Sudipto RoyInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, 61 Biopolis Drive, Singapore 138673, Singapore.
Kathryn E HentgesDivision of Evolution, Infection and Genomics, BHF Manchester Centre of Research Excellence, School of Biological Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, M13 9PT, UK.ORCID 0000-0001-8917-3765
Funding
Wellcome Trust
Abstract
Cilia function in the left-right organizer (LRO) is critical for determining internal organ asymmetry in vertebrates. To further understand the genetics of left-right asymmetry, we isolated a mouse mutant with laterality defects,
Indexed as
ARL13Bciliaciliopathyembryonic developmentIFTleft-right axismutagenesis screenPRPF8retinitis pigmentosasplicing
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.