Evidence map›Paper›PMID 40501565›Full record

ArticlebioRxiv : the preprint server for biology2025

A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling.

Jackson R Griffiths, Melissa Miller, Timothy J Duerr, Ashlin E Owen, James R Monaghan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jackson R GriffithsNortheastern University, Department of Biology, Boston, MA.ORCID 0000-0002-4115-8993
Melissa MillerNortheastern University, Department of Biology, Boston, MA.
Timothy J DuerrNortheastern University, Department of Biology, Boston, MA.
Ashlin E OwenNortheastern University, Department of Biology, Boston, MA.
James R MonaghanNortheastern University, Department of Biology, Boston, MA.

Funding

Ambystoma Genetic Stock Center - Revision to Include Curation and Informatics ComponentP40OD019794 · OD · UNIVERSITY OF KENTUCKY · PI Stephen Randal Voss · 2015 to 2026
$6.3M
Mechanisms of skeletal patterning during limb development and regenerationR01HD099174 · NICHD · NORTHEASTERN UNIVERSITY · PI MONAGHAN, JAMES R · 2020 to 2024
$1.6M
NICHD NIH HHS R01 HD099174NIH HHS P40 OD019794
6 · The paper itself

Abstract

Axolotl digits offer an experimentally versatile model for studying complex tissue regeneration. Here, we provide a comprehensive morphological and molecular characterization of digit regeneration, revealing both conserved features and notable divergences from classical limb regeneration. Digit blastemas progress through similar morphological stages, are nerve-dependent, contain key regenerative cell populations, and express many canonical morphogens and mitogens. However, they exhibit minimal expression of the A-P patterning genes

Indexed as

AxolotlDigitHedgehog signalingNerve DependencyPatterningRegeneration

Identifiers

PMID40501565
PMCPMC12157609

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.