Evidence map›Paper›PMID 40501520›Full record

ArticleJournal of hematology2025

Light Chain (AL) Amyloidosis Masquerading as Scleroderma: A Diagnostic Challenge.

Kriti Dhamija, Rahim A Jiwani, Arjun Lakshaman, Santhosh Sadashiv, Prerna Mewawalla

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kriti DhamijaMedicine Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.ORCID https://orcid.org/0009-0006-1651-3208
Rahim A JiwaniDivision of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Arjun LakshamanDivision of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Santhosh SadashivDivision of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Prerna MewawallaDivision of Hematology and Cellular Therapy, Allegheny Health Network Cancer Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic amyloidosis has diverse, often nonspecific, clinical manifestations that overlap or mimic other medical disorders, making amyloidosis a diagnostic challenge. We present a case of a middle-aged female who presented with skin thickening, fatigue, arthritis, and macroglossia, which were initially thought to be due to systemic sclerosis. With no response to immunosuppressive therapies, she was tested for plasma cell dyscrasias. Additional work-up and cardiac biopsy were positive for amyloid light chain (AL) amyloidosis. The diagnosis was delayed by 2 years because the protein electrophoresis ordered at the initial encounter was not accompanied by serum-free light chain testing. This case emphasizes the importance of considering amyloidosis in patients with unexplained systemic symptoms and highlights the role of a comprehensive diagnostic evaluation.

Indexed as

AmyloidosisCongo red stainingFree light chainSmoldering multiple myeloma

Identifiers

PMID40501520
PMCPMC12151118

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.