Evidence map›Paper›PMID 40501121›Full record

ArticleCNS neuroscience & therapeutics2025

Task-Evoked Theta Oscillation Dysregulation Underlies Attention Network Deficits in Left Temporal Lobe Drug-Resistant Epilepsy.

Changqing Zhan, Qiao Wang, Wenyu Wang, Na Pan, Jieju Feng, Zonghan Yang, Shizao Fei, Zongsheng Chen, Yingnian Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Changqing ZhanDepartment of Neurology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.ORCID 0000-0002-9646-2909
Qiao WangDepartment of Pathology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.
Wenyu WangDepartment of Neurology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.
Na PanDepartment of Neurological Rehabilitation, Anhui Wannan Rehabilitation Hospital (Wuhu No. 5 People's Hospital), Wuhu, Anhui, China.
Jieju FengDepartment of Neurology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.
Zonghan YangDepartment of Neurology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.
Shizao FeiDepartment of Neurology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.
Zongsheng ChenDepartment of Neurology, Wuhu No. 2 People's Hospital, Wuhu, Anhui, China.
Yingnian ChenDepartment of Neurological Rehabilitation, Anhui Wannan Rehabilitation Hospital (Wuhu No. 5 People's Hospital), Wuhu, Anhui, China.

Funding

Anhui Province clinical medical research transformation project 202304295107020091Health Research Project of Anhui Province AHWJ2024Aa30098Wuhu City health Commission scientific research project WHWJ2023y034
6 · The paper itself

Abstract

aimsThis study investigated the neural mechanisms of left temporal lobe drug-resistant epilepsy (DRE) with attention network dysfunction using the attention network test (ANT) and synchronous electroencephalography (EEG).

methodsThis study enrolled three cohorts: 20 patients with left temporal lobe drug-resistant epilepsy (DRE group), 20 left temporal lobe drug-sensitive epilepsy (DSE group) patients, and 20 age-/sex-matched healthy controls (Ctrl group). Participants completed standardized ANT tasks while scalp EEG was recorded at a 1000 Hz sampling rate. We computed power spectral density (PSD) of neural oscillations from ANT-task EEG epochs.

resultsDRE patients exhibited significantly impaired network efficiency across executive control (EC), alerting, and orienting networks. Compared to the Ctrl group, both DRE and DSE groups demonstrated reduced frontal theta PSDs in EC, alerting, and orienting networks (all p < 0.001), with the DRE group showing greater deficits than the DSE group in the EC network (p < 0.001). Additionally, Significant correlations emerged between frontal theta PSD and behavior in Ctrl (EC

conclusionDrug-resistant epilepsy patients have dysfunctional attention network behavior and decreased theta band PSDs in the frontal lobe. It is possible that decreased theta oscillations in the frontal lobe may contribute to ANT behavior dysfunction in drug-resistant epilepsy patients.

Indexed as

AttentionDrug Resistant EpilepsyEpilepsy, Temporal LobeNerve NetTheta RhythmAdultElectroencephalographyExecutive FunctionFemaleHumansMaleMiddle AgedYoung Adultattention networkdrug‐resistant epilepsyneural oscillationtheta

Identifiers

PMID40501121
PMCPMC12159323

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.