Evidence map›Paper›PMID 40501119›Full record

ArticleCancer biomarkers : section A of Disease markers2025

Knockdown of MACC1 expression attenuates colorectal cancer cell glucose metabolism by suppressing GLUT4 membrane translocation.

Qingke Li, Yankun Liu, Zhiwu Wang, Yufeng Li, Lifang He, Jingwu Li

Abstract read
In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qingke LiDepartment of Gastrointestinal Surgery, Tangshan People's Hospital, Tangshan City, China.ORCID 0009-0006-3621-0327
Yankun LiuMedical Molecular Diagnosis Department of Cancer Research Institute, Tangshan People's Hospital, Tangshan City, China.
Zhiwu WangRadiochemotherapy Department, Tangshan People's Hospital, Tangshan City, China.
Yufeng LiCentral Laboratory, Tangshan People's Hospital, Tangshan City, China.
Lifang HeNephrology Department, Tangshan People's Hospital, Tangshan City, China.
Jingwu LiDepartment of Gastrointestinal Surgery, Tangshan People's Hospital, Tangshan City, China.ORCID 0000-0002-7851-5624

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundMetastasis-associated in colon cancer-1 (MACC1) is a novel oncogene involved in the growth and metastasis of tumors, which is overexpression in various tumors. MACC1 could promote the growth, invasion, and metastasis of colorectal cancer (CRC) by activating the HGF/MET signaling pathway

Indexed as

Colorectal NeoplasmsGlucoseGlucose Transporter Type 4Trans-ActivatorsTranscription FactorsCell ProliferationGene Expression Regulation, NeoplasticGene Knockdown TechniquesGlycolysisHCT116 CellsHT29 CellsHumansProtein TransportGlucoseGlucose Transporter Type 4MACC1 protein, humanSLC2A4 protein, humanTrans-ActivatorsTranscription Factorscolorectal cancerglucose metabolismGLUT4MACC1

Identifiers

PMID40501119
PMCPMC12288408

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.