Evidence map›Paper›PMID 40501066›Full record

ArticleAnnals of clinical and translational neurology2025

Active Seizures Predict Worse Instrumental Activities of Daily Living in Individuals With Normal Cognition and Dementia.

Ifrah Zawar, Jaideep Kapur, Meghan M Mattos, Carol Manning, Syeda Amrah Hashmi, Mark Quigg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ifrah ZawarComprehensive Epilepsy Program, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-6103-4250
Jaideep KapurComprehensive Epilepsy Program, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0002-8608-1352
Meghan M MattosSchool of Nursing, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0001-7355-7190
Carol ManningMemory Disorders Program, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Syeda Amrah HashmiComprehensive Epilepsy Program, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Mark QuiggComprehensive Epilepsy Program, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.ORCID 0000-0003-3035-9260

Funding

THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Clinical Coordinating Center Network of Excellence in Neuroscience Clinical TrialU01NS077179 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Merit E CUDKOWICZ, Aleksandar Videnovic · 2011 to 2026
$43.4M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0M
VESICULAR LOCALIZATION AND FUNCTION OF PRESENILIN 1 FRAGMENTP50AG005138 · NIA · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI GROSSMAN, HILLEL · 1985 to 2019
$37.9M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI BANDEEN-ROCHE, KAREN J. · 1985 to 2019
$37.6M
Alzheimer's Association AACSFD-22-974008American Epilepsy Society 1067206BAND FoundationHRSA HHS 4 U1QHP287440400NIA NIH HHS K23 AG084893NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG008051NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG035982NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005133NIA NIH HHS P50 AG005134NIA NIH HHS P50 AG005136NIA NIH HHS P50 AG005138NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016573NIA NIH HHS P50 AG016574NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG033514NIA NIH HHS P50 AG047266NIA NIH HHS P50 AG047270NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG068128NIA NIH HHS R01 AG072430NIA NIH HHS R21 AG080377NIA NIH HHS R44 AG062072NIA NIH HHS U24 AG072122NIH HHS 1K23AG084893-01A1NIH HHS 1R01AG072430-01A1NIH HHS 1R21AG080377-01NIH HHS 2R44AG062072NIH HHS 2U01NS077179-13NIH HHS 5UH3NS123308-02NIH HHS R01AG068128NIH HHS R01NS120945NIH HHS R37NS119012NINDS NIH HHS R01 NS120945NINDS NIH HHS R37 NS119012NINDS NIH HHS U01 NS077179NINDS NIH HHS UH3 NS123308
6 · The paper itself

Abstract

objectivesCognitive disorders are common in older persons with seizures (PWS). Cognitive disorders are often associated with impaired Instrumental Activities of Daily Living (IADLs). However, the effects of seizures on IADLs remain unexplored. This study (9/2005-3/2024) from 42 US Alzheimer's Disease Research Centers examined baseline and longitudinal IADL decline in cognitively normal and cognitively impaired participants grouped as active seizures (past 12 months), remote seizures (history but none in 12 months), and controls (no seizures).

methodsPfeffer Functional Activities Questionnaire (FAQ) measured IADLs. ANOVA compared individual and total FAQ by seizure and cognitive status. Multivariable linear regression adjusted FAQ for seizure status, age, sex, and education. ANOVA compared the rate of longitudinal FAQ decline across seizure groups. Post hoc analyses identified group differences.

resultsAmong 20,486 cognitively normal participants (average age = 69.7 years, female = 65% [N = 13,370]), IADLs were worse among 114 active seizure participants (adjusted-mean-difference [95% confidence interval (CI)]: active vs. remote = 0.69 (0.23, 1.14), p = 0.0011, active vs. controls = 0.85 (0.46, 1.24), p < 0.001). Among 30,238 cognitively impaired participants (average age = 72.2 years, female = 52% [N = 15,632]), IADLs were worse among 735 active seizure participants (adjusted-mean-difference (95% CI): active vs. remote = 6.85 (5.59, 8.10), p < 0.001, active vs. controls = 8.93 (8.06, 9.80), p < 0.001). Longitudinally, IADLs in cognitively normal adults declined faster in active seizure participants than in controls (p = 0.0396). Active seizure participants struggled most with managing taxes, traveling, paying bills, and remembering appointments.

interpretationActive seizures are associated with worse baseline IADLs and a faster rate of longitudinal decline in IADLs. These findings highlight the significant need to assess IADLs in routine clinical care in older PWS regardless of their cognition to identify those needing assistance.

Indexed as

Activities of Daily LivingCognitionCognitive DysfunctionDementiaSeizuresAgedAged, 80 and overFemaleHumansLongitudinal StudiesMaleMiddle Agedactive seizurescognitiondementiaepilepsyFAQinstrumental activities of daily livingolder adultspersons with seizuresseizures

Identifiers

PMID40501066
PMCPMC12343324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.