Evidence map›Paper›PMID 40500965›Full record

ReviewPlant communications2025

Transcriptional activation and repression in the plant circadian clock: Revisiting core oscillator feedback loops and output pathways.

Jing Li, Ming-Kang Yang, Jian Zeng, Liang Chen, Wei Huang

Abstract readReview
In one paragraph

Review in Plant communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing LiGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, School of Biology and Agriculture, Shaoguan University, Shaoguan 512005, Guangdong, China.
Ming-Kang YangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, Guangdong, China.
Jian ZengGuangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, School of Biology and Agriculture, Shaoguan University, Shaoguan 512005, Guangdong, China.
Liang ChenGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, Guangdong, China.
Wei HuangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, Guangdong, China. Electronic address: weihuang@scau.edu.cn.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

The plant circadian clock operates through interconnected transcriptional-translational feedback loops, comprising circadian-regulated transcriptional activators and repressors at the core oscillator. These transcription factors (TFs) not only regulate the timing of gene expression within the oscillator but also orchestrate downstream transcriptomic regulation in output pathways by directly binding to promoters of key genes. To date, most plant TFs identified in these loops are transcriptional repressors, supporting a clock model dominated by repressive interactions. However, a number of studies have reported the presence of transcriptional activators in newly identified feedback loops. Interestingly, some TFs can function as both activators and repressors of circadian-regulated genes, offering new insights into clock regulatory mechanisms. This review revisits transcriptional activation and repression in core oscillator genes, offering a conceptual framework to advance the understanding of their roles, particularly in the regulation of clock output pathways.

Indexed as

Circadian ClocksGene Expression Regulation, PlantTranscriptional ActivationCircadian RhythmFeedback, PhysiologicalPlant ProteinsTranscription FactorsPlant ProteinsTranscription Factorscircadian clockclock componentsoutput pathwaysplantstranscriptional activityTTFLs

Identifiers

PMID40500965
PMCPMC12365851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.