ReviewAdvanced healthcare materials2025
Advanced Oral Delivery Systems for Nutraceuticals.
Review in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Advanced Oral Delivery Systems for Nutraceuticals.Advanced healthcare materials · 2025Review
- 2D materials for nutraceutical delivery and smart packaging: multifunctional, sustainable, and responsive applications.RSC advances · 2025Review
- Current Status and Future Prospects on Nanodelivery Systems Targeting the Small Intestine for Absorption of Bioactive Substances.Foods (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral delivery is the most preferred route for nutraceuticals due to its convenience and high patient compliance. However, bioavailability is often compromised by poor solubility, instability, and first-pass metabolism in the gastrointestinal tract. This review examines current and emerging oral delivery platforms designed to overcome these barriers and enhance nutraceutical efficacy. Traditional carriers-proteins, lipids, and carbohydrates-highlighting their delivery mechanisms and limitations, are first explored. Advancements in material science have led to novel platforms such as biodegradable polymers, metal-organic frameworks (MOFs), metal-polyphenol networks (MPNs), and 3D printing technologies. Biodegradable polymers improve stability and enable controlled release of bioactives. MOFs offer high surface area and tunable porosity for encapsulating and protecting sensitive compounds. MPNs provide biocompatible, stimuli-responsive systems for targeted nutrient delivery. Meanwhile, 3D printing facilitates the fabrication of personalized delivery systems with precise control over composition and release kinetics, especially when integrated with artificial intelligence (AI) for precision nutrition. By comparing traditional and next-generation strategies, this review outlines key design principles for optimizing oral delivery systems. The transformative potential of these innovations is underscored to improve the bioavailability and therapeutic outcomes of nutraceuticals, ultimately advancing personalized and targeted nutrition solutions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.