ArticleOrphanet journal of rare diseases2025
Factors associated with psycho-behavioral problems among 100 children with phenylketonuria aged 6-18 years.
Article in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhenylketonuria (PKU) is a rare disease. Children who are diagnosed with PKU often encounter psycho-behavioral difficulties, which can significantly impact quality of life and social integration. The aim of this study was to evaluate the prevalence of psycho-behavioral difficulties and explore potential factors associated with their occurrence in PKU children aged 6-18 years.
methodsFrom May 2022 to May 2024, 100 children with PKU were recruited using a questionnaire-based survey. Data were analyzed using the STATA (version 18.0) and R programming language (version 4.3.3).
results25% of children aged 6-18 years with PKU exhibited psycho-behavioral problems. Significant factors associated with psycho-behavioral problems in study children included body mass index (multi-adjusted odds ratio, 95% confidence interval, P: 1.135, 1.010-1.276, 0.033), age (3.169, 1.024-9.804, 0.045), pregnancy order (0.143, 0.033-0.607, 0.008), delivery order (0.041, 0.004-0.373, 0.005), mode of disease diagnosis (5.730, 1.935-16.963, 0.002), and dietary therapy pressure (3.321, 1.083-10.181, 0.036). Based on these significant factors, a nomogram model was constructed with descent prediction capability and accuracy.
conclusionsWe identified six factors closely associated with psycho-behavioral problems in PKU children, offering insights into risk profiles underlying these problems and guiding the formulation of effective prevention strategies.
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