ArticlePorcine health management2025
Zoonotic rat hepatitis E virus infection in pigs: farm prevalence and public health relevance.
Article in Porcine health management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Hospital Admissions for Hepatitis A and E in Spain: Nationwide Trends and In-Hospital Outcomes.Journal of medical virology · 2026Article
- Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact.Nature communications · 2026Review
- Genomic characterization of novel orthohepeviruses in shrews and rats from Kenya.Microbial genomics · 2025Article
- Prevalence, Risk Factors, and Genetic Evolution of Rat Hepatitis E Virus in Small Mammals from Southwestern Yunnan, China.Biology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Rat hepatitis E virus (ratHEV) is an emerging zoonotic pathogen causing acute and chronic hepatitis, with zoonotic transmission pathways that remain unclear. While rats are its primary reservoir, recent experimental studies revealed that pigs are susceptible to ratHEV infection. To better understand its epidemiology, we assessed the herd prevalence of ratHEV in 64 extensively managed pig farms in southwestern Spain. Serum samples from 1,861 animals were pooled and analyzed using a multiplex qPCR. Viral RNA was detected in 9 (1.9%) of the 466 analyzed pools, with a herd prevalence of 10.9% (7/64; 95%CI: 5.4-20.9). Positive farms were distributed across the study area, and ratHEV circulation was limited to fattening farms (17.5%) (P = 0.007). These findings suggest pigs could act as intermediate hosts between rats and humans, posing a public health risk. Enhanced surveillance in pig farms and pork products is crucial to assess zoonotic transmission risks.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.