ArticleJournal of medicinal chemistry2025
Could Hydrophobicity of Sulfated Pseudo-Trisaccharides Derived from Repurposing Aminoglycoside Tobramycin Modulate the Enzymatic Activity of Heparanase?
Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Synthetic Heparan Sulfate-like Oligosaccharides as Tools to Decipher Growth Factor Recognition.Journal of medicinal chemistry · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Heparanase (HPSE) remodeling of the extracellular matrix makes it a crucial therapeutic target. The development of effective glycan-based HPSE inhibitors has been limited by bleeding and thromboembolic disorders. In this report, we present a structure-based design approach that rapidly generates a library of potent and selective HS mimetics, synthesized in 8 to 9 steps from readily available aminoglycoside tobramycin. Computational analyses indicate that hydrophobic molecular markers modulate HPSE activity. Consequently, we identified naphthalene-based
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Registered trials
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