Evidence map›Paper›PMID 40500659›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Enhancing working memory in MCI: Modulating alpha-gamma coupling and gamma oscillations via rTMS.

Xiao Yuan, Xiaochen Zhang, Jingnan Sun, Renren Li, Jing Ma, Chenxi Pan, Meng Liu, Hualan Yang, Dan Yang, Fangyun Li and 3 more

Abstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiao YuanDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Xiaochen ZhangDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Jingnan SunSchool of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.
Renren LiDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Jing MaDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Chenxi PanDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Meng LiuDepartment of Neurology, Changhai Hospital, The First Affilitated Hospital of Naval Medical University of PLA, Shanghai 200433, China.
Hualan YangDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Dan YangDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Fangyun LiDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Zhi BieDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
Zhen HuDepartment of Neurology, RuiJin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address: zhenhudoctor@163.com.
Yunxia LiDepartment of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai, China. Electronic address: doctorliyunxia@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cross-frequency coupling (CFC), particularly the interaction between alpha and gamma oscillations, is a pivotal mechanism implicated in cognitive function, with potential for modulation by repetitive transcranial magnetic stimulation (rTMS). This study aimed to investigate the impact of high-frequency rTMS (HF rTMS) on CFC and visual working memory (VWM) in individuals with mild cognitive impairment (MCI). Twenty MCI patients and twenty healthy controls were administered 10Hz rTMS targeting the left dorsolateral prefrontal cortex (DLPFC). Our critical findings indicate that post-intervention, MCI patients exhibited significant enhancements in VWM performance, notably under low memory load. These improvements correlated with a reduction in occipital gamma activity, and were concurrent with strengthened phase-amplitude coupling (PAC) between frontal alpha and occipital gamma oscillations. The results underscore the capacity of alpha-band HF rTMS to modulate neural activity, offering a promising, non-invasive strategy for enhancing cognitive performance in MCI.

Indexed as

Alpha RhythmCognitive DysfunctionGamma RhythmMemory, Short-TermTranscranial Magnetic StimulationAgedAged, 80 and overCase-Control StudiesDorsolateral Prefrontal CortexElectroencephalographyFemaleHumansMaleMiddle AgedPhotic StimulationTreatment OutcomeCross-frequency couplingMild cognitive impairmentOccipital gamma activityTranscranial magnetic stimulationWorking memory

Identifiers

PMID40500659
PMCPMC12491797

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.