Evidence map›Paper›PMID 40500629›Full record

ReviewTrends in molecular medicine2025

Fibroblasts in AKI: small army, big help.

Saiya Zhu, Yuan Gui, Jia-Jun Liu, Silvia Liu, Dong Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Macrophage-Fibroblast Crosstalk in Kidney Injury: A Narrative Review.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saiya ZhuDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Yuan GuiDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, USA.
Jia-Jun LiuOrgan Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Silvia LiuOrgan Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
Dong ZhouDivision of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, USA. Electronic address: dzhou@uchc.edu.

Funding

Importance of cell-matrix interactions in kidney repair after acute kidney injuryR01DK132059 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Dong Zhou · 2023 to 2026
$1.9M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
Early and Transient Activation of Fibroblasts Promotes Tubule Repair after Acute Kidney InjuryK01DK116816 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZHOU, DONG · 2019 to 2021
$509k
The formation of kidney local microenvironment after acute kidney injury.R03DK128529 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHOU, DONG · 2021 to 2022
$246k
NIDDK NIH HHS K01 DK116816NIDDK NIH HHS R01 DK132059NIDDK NIH HHS R03 DK128529NIH HHS S10 OD028483
6 · The paper itself

Abstract

Acute kidney injury (AKI), with high morbidity and mortality, stems from tubular injury, vascular damage, and inflammation. Although often overlooked, early fibroblast activation is critical for kidney repair, challenging traditional associations of fibroblasts with fibrosis. Here, we summarize fibroblast origins, heterogeneity, functions, and therapeutics in preventing or mitigating AKI.

Indexed as

Acute Kidney InjuryFibroblastsKidney TubulesRegenerationAnimalsCellular ReprogrammingDisease Models, AnimalExtracellular MatrixHumansMycophenolic AcidMycophenolic Acidacute kidney injuryfibroblastheterogeneitymicroenvironment

Identifiers

PMID40500629
PMCPMC12616572

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.