Evidence map›Paper›PMID 40500611›Full record

ReviewTrends in cognitive sciences2025

The interoceptive origin of reinforcement learning.

Lilian A Weber, Debbie M Yee, Dana M Small, Frederike H Petzschner

Abstract readReview
In one paragraph

Review in Trends in cognitive sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. When does post-ingestive dopamine signaling occur in humans?bioRxiv : the preprint server for biology · 2026
    Article
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  3. Article
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lilian A WeberDepartment of Psychiatry, University of Oxford, Oxford, UK; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, University of Oxford, Oxford, UK.
Debbie M YeeCognitive and Psychological Sciences, Brown University, Providence, RI, USA; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA.
Dana M SmallDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada; Department of Medicine, McGill University, Montreal, QC, Canada; Department of Psychology, McGill University, Montreal, QC, Canada; Research Institute of the McGill University Health Center (RI-MUHC), McGill University, Montreal, QC, Canada; Modern Diet and Physiology Research Center, New Haven, CT, USA. Electronic address: dana.small@mcgill.ca.
Frederike H PetzschnerCognitive and Psychological Sciences, Brown University, Providence, RI, USA; Robert J. and Nancy D. Carney Institute for Brain Science, Brown University, Providence, RI, USA. Electronic address: frederike_petzschner@brown.edu.

Funding

The neural basis of sequential control in human and non-human primatesP20GM103645 · NIGMS · BROWN UNIVERSITY · PI SANES, JEROME N · 2013 to 2022
$22.9M
Brown Postdoctoral Training Program in Computational PsychiatryT32MH126388 · NIMH · BROWN UNIVERSITY · PI MICHAEL J. FRANK, STEPHANIE Ruggiano JONES · 2021 to 2026
$2.1M
Advancing the Research Careers of Women and PEERs in Brain ScienceR25NS124530 · NINDS · BROWN UNIVERSITY · PI CARLOS D AIZENMAN, Diane Lipscombe · 2022 to 2026
$1.3M
Neurocomputational mechanisms of serotonin, sustained stress, and mental effort allocationK99MH133912 · NIMH · BROWN UNIVERSITY · PI YEE, DEBBIE · 2024 to 2025
$230k
NIGMS NIH HHS P20 GM103645NIMH NIH HHS K99 MH133912NIMH NIH HHS T32 MH126388NINDS NIH HHS R25 NS124530Wellcome Trust
6 · The paper itself

Abstract

Rewards play a crucial role in sculpting all motivated behavior. Traditionally, research on reinforcement learning has centered on how rewards guide learning and decision-making. Here, we examine the origins of rewards themselves. Specifically, we discuss that the critical signal sustaining reinforcement for food is generated internally and subliminally during the process of digestion. As such, a shift in our understanding of primary rewards as an immediate sensory gratification to a state-dependent evaluation of an action's impact on vital physiological processes is called for. We integrate this perspective into a revised reinforcement learning framework that recognizes the subliminal nature of biological rewards and their dependency on internal states and goals.

Indexed as

InteroceptionLearningReinforcement, PsychologyRewardAnimalsHumansallostasisdopaminehomeostasisinteroceptionstriatumvalue

Identifiers

PMID40500611
PMCPMC12400946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.