Evidence map›Paper›PMID 40500582›Full record

ArticleTranslational stroke research2025

Gut Microbiota Improve the Prediction of Stroke-Associated Pneumonia Risk and Outcomes in Acute Ischemic Stroke.

Yi-Si Lin, Jia-Hao Chen, Wei-Hao Zhuang, Jia-Ni Huang, Yi-Han Chen, Jie Zhang, Jia Li, Meng Huang, Jia-Long Hou, Shuang-Jie Qian and 3 more

Abstract read
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In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yi-Si Lin *Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Jia-Hao Chen *Department of Neurology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Zhejiang Province, Jinhua, China.
Wei-Hao ZhuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Jia-Ni HuangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Yi-Han ChenThe Second School of Clinical Medicine, Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Jie ZhangThe Second School of Clinical Medicine, Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Jia LiDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Meng HuangThe First School of Clinical Medicine, Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Jia-Long HouDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Shuang-Jie QianDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Zhi-Bo ChenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China.
Yan-Lei ZhangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China. 17123527@qq.com.
Ruo-Ting XuDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou, China. 331523317@qq.com.

Funding

the Medical and Health Science and Technology Project of Zhejiang Province 2025KY1002the Projects of Natural Science Foundation of Zhejiang Province LQ23H090005Wenzhou Municipal Science and Technology Bureau Y20210170Wenzhou Municipal Science and Technology Bureau Y20220817
6 · The paper itself

Abstract

Stroke-associated pneumonia (SAP) is the most significant acute ischemic stroke (AIS) comorbidity. This investigation aimed to explore the relationship between gut microbiome composition and SAP risk in patients with moderate-to-severe AIS and to develop a robust and accessible SAP risk-prediction model for this population. This prospective study included AIS patients with an NIHSS score ≥ 9 within 48 h of onset who were admitted to the First Affiliated Hospital of Wenzhou Medical University. Rectal swabs and sputum samples were collected for 16S rRNA gene sequencing and analyzed via QIIME to evaluate microbial composition. Blood samples were subjected to untargeted metabolomics analysis via liquid chromatography‒mass spectrometry (LC‒MS). Logistic and Cox regression analyses were conducted (α = 0.05). Fifty of 104 AIS patients (48.1%) developed SAP. Microbiota abundances significantly differed between groups. Logistic regression analysis revealed that Finegoldia protected against SAP (OR 0.710, 95% CI: 0.533 - 0.946, p = 0.019), whereas Lactobacillus (OR 1.347, 95% CI: 1.015 - 1.789, p = 0.039) increased SAP risk. An improved SAP prediction model combining the A

Indexed as

Gastrointestinal MicrobiomeIschemic StrokePneumoniaAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsGut microbiomeMetabolitesPredictive modelStrokeStroke-associated pneumonia

Identifiers

PMID40500582

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.