ReviewNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease.
Review in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Therapeutic Potential of Kuwanon G: From Bioactivities to Network-Level Mechanisms.Molecules (Basel, Switzerland) · 2026Review
- The Emerging Parkinson's Disease Oxylipin-Ome.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This comprehensive review meticulously examines the pivotal and multifaceted role of G protein-coupled receptors (GPCRs) in the complex pathogenesis of Parkinson's disease (PD), a neurodegenerative disorder that profoundly impacts motor control and cognitive function. Initially, we introduce the fundamental concepts of GPCRs, delving into their intricate structures and diverse functions within the nervous system, highlighting their importance as key players in cellular communication and signal transduction. Following this foundational overview, we thoroughly analyze specific GPCRs that have been closely associated with the onset and progression of PD, exploring the intricate mechanisms by which they influence disease progression through the nuanced regulation of neurotransmitter release, complex signaling pathways, and crucial aspects of cell survival. Furthermore, we engage in a detailed discussion regarding the promising prospects of GPCRs as potential therapeutic targets for intervention in PD, emphasizing the significance of recent groundbreaking research findings that shed light on the therapeutic implications of modulating GPCR activity. Finally, drawing upon the latest advancements in research, we propose insightful directions for future studies, as well as a thoughtful consideration of the myriad challenges that lie ahead in this dynamic and rapidly evolving field of study, which holds the potential to enhance our understanding of PD and pave the way for innovative treatment strategies.
Indexed as
Identifiers
40500561What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.