Evidence map›Paper›PMID 40500547›Full record

ArticleJournal of cardiovascular translational research2025

Modeling the Hemodynamic Impact of Y-incision Aortic Annular Enlargements on Aortic Valve Replacement and Valve-in-Valve Procedures.

Mia Bonini, Surya Sanjay, Maximilian Balmus, Alexander Makkinejad, Katelyn Monaghan, Marc Hirschvogel, Nicholas Burris, Bo Yang, David Nordsletten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mia Bonini *Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. mbonini@umich.edu.ORCID 0000-0003-0860-6931
Surya Sanjay *Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Maximilian BalmusDepartment of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Alexander MakkinejadDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, MI, USA.
Katelyn MonaghanDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, MI, USA.
Marc HirschvogelMOX, Dipartimento di Matematica, Politecnico di Milano, Milan, Italy.
Nicholas BurrisDepartment of Radiology, Michigan Medicine, Ann Arbor, MI, USA.
Bo YangDepartment of Cardiac Surgery, Michigan Medicine, Ann Arbor, MI, USA.
David NordslettenDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Funding

Therapeutic Insights into Loeys-Dietz Syndrome using Humanized ModelsR01HL151776 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bo Yang · 2020 to 2026
$4.2M
Define the mechanisms of aortopathy in bicuspid aortic valve patientsR01HL141891 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YANG, BO · 2018 to 2022
$3.5M
NHLBI NIH HHS R01 HL141891NHLBI NIH HHS R01 HL151776NIH HHS R01HL141891NIH HHS R01HL151776
6 · The paper itself

Abstract

Y-incision aortic annular enlargement (Y-AAE) with surgical aortic valve replacement (SAVR) may improve outflow tract hemodynamics and valve-in-valve (ViV) outcomes but could increase thrombosis risk. We used computational fluid dynamics to analyze post-operative hemodynamics in 15 patient-specific SAVR models, comparing cases with and without Y-AAE. ViV scenarios were simulated by virtually deploying transcatheter aortic valves. Transvalvular peak velocities, pressure gradients, and blood residence time (a proxy for hemostatic risk) were analyzed to assess performance across cases. Y-AAE reduced peak velocity by 39.3% (55% in ViV), transvalvular pressure gradient by 87.2% (92% in ViV), and mean blood residence time by 10.3% (14% in ViV), with no consistent difference in maximum residence time. SAVR with Y-AAE demonstrated improved hemodynamics, even with ViV procedures, and no evidence of increased thrombosis risk.

Indexed as

Aortic ValveAortic Valve StenosisHeart Valve Prosthesis ImplantationHemodynamicsModels, CardiovascularPatient-Specific ModelingTranscatheter Aortic Valve ReplacementAgedFemaleHeart Valve ProsthesisHumansMaleProsthesis DesignRisk FactorsThrombosisTreatment OutcomeAortic valve replacementBlood stasisComputational fluid dynamicsValve-in-valveY-incision aortic annular enlargement

Identifiers

PMID40500547
PMCPMC12436585

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.