Toward isolating perceptual and physiological contributors to heat sensitivity in multiple sclerosis: insights from a new experimental model.

Timothy English, Joshua Barton, Nicole Vargas, Michael Barnett, Ollie Jay

Abstract read

In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Timothy EnglishHeat and Health Research Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.

Joshua BartonBeach Brain, Southern Cross University Hospital, Birtinya, Australia.

Nicole VargasInstitute for Climate, Energy and Disaster Solutions, College of Health and Medicine, Australian National University, Acton, Australia.

Michael BarnettMultiple Sclerosis Clinic, Brain and Mind Centre, University of Sydney, Sydney, Australia.

Ollie JayHeat and Health Research Centre, Faculty of Medicine and Health, University of Sydney, Sydney, Australia. ollie.jay@sydney.edu.au.ORCID http://orcid.org/0000-0002-6076-6337

Funding

Multiple Sclerosis Research Australia 17-0227

6 · The paper itself

Abstract

purposeTo determine if reductions in whole-body thermal sensation (WBTS) with localised skin cooling mitigate heat-induced visual performance decrements in people with multiple sclerosis (MS), optic neuritis, and heat-sensitive visual symptoms, independent of core temperature increases.

methodsThirteen participants (7 relapsing-remitting MS (MS) patients with unilateral (left) optic neuritis and heat-sensitive visual symptoms; 6 controls) underwent visual performance testing on each eye at baseline and during passive heating (0.6℃ rise in gastrointestinal temperature (ΔT

resultsΔT

conclusionLocalised skin cooling during passive heating to a moderate core temperature produces only a modest reduction in WBTS and does not mitigate heat-induced visual performance decrements. The limited perceptual difference achieved suggests the localised skin cooling was insufficient to meaningfully isolate the effects of skin temperature from core temperature.

Indexed as

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingOptic NeuritisThermosensingAdultContrast SensitivityEvoked Potentials, VisualFemaleHot TemperatureHumansMaleMiddle AgedHeatMultiple sclerosisNeural conductionSkin coolingSymptomVisual evoked potentials

Identifiers

PMID40500533

DOI10.1007/s00421-025-05838-7

PMCPMC12528202

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.