Evidence map›Paper›PMID 40500508›Full record

ArticleMikrochimica acta2025

Doxorubicin detection in plasma and blood using a luminescence turn-off nanosensor based on alloyed CdZnSeS/ZnS quantum dots.

Svetlana A Mescheryakova, Daria G Koganova, Daria V Tsyupka, Danila A Kornilov, Pavel S Pidenko, Daniil D Drozd, Olga A Goryacheva, Irina Yu Goryacheva

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Svetlana A MescheryakovaSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia. meshcheryakova.s.a@gmail.com.
Daria G KoganovaSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.
Daria V TsyupkaSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.
Danila A KornilovSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.
Pavel S PidenkoSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.
Daniil D DrozdSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.
Olga A GoryachevaSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.
Irina Yu GoryachevaSaratov State University Named After N.G. Chernyshevsky, Astrakhanskaya 83, 410012, Saratov, Russia.

Funding

Russian Science Foundation 23-13-00380
6 · The paper itself

Abstract

The feasibility of doxorubicin (Dox) detection in plasma and blood using a luminescence turn-off nanosensor based on alloyed CdZnSeS/ZnS quantum dots (QDs) is demonstrated. The QD luminescence quenching in the presence of Dox was carefully examined. Optimal assay conditions were selected, including plasma dilution and QD concentration. The calculated limit of detection value was 0.02 µg/mL. Time-resolved QD luminescence quenching and absorption measurements allowed us to determine that the quenching process occurs via a combined mechanism. At low Dox concentrations, the dynamic quenching is predominant, while at Dox concentrations above 2.5 μM, the contribution of static quenching increases drastically. Dox detection in whole human blood was performed and compared with other methods for the drug detection in blood. The results of the method are comparable with those of the high-performance liquid chromatography with ultraviolet-visible detection.

Indexed as

Cadmium CompoundsDoxorubicinQuantum DotsSelenium CompoundsSulfidesZinc CompoundsAlloysHumansLimit of DetectionLuminescent MeasurementsAlloysCadmium Compoundscadmium selenideDoxorubicinSelenium CompoundsSulfidesZinc Compoundszinc sulfideAnthracycline antibioticsDoxorubicinHuman plasmaLuminescence quenchingNanosensorQuantum dots

Identifiers

PMID40500508

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.