SynthesisLangenbeck's archives of surgery2025
Indocyanine green and height of anastomosis in colorectal surgery- a network meta-analysis.
Synthesis in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Indocyanine green in intestinal endometriosis surgery: a multicenter evaluation of anastomotic safety.Journal of robotic surgery · 2026Observational
- Improved Quantification of ICG Perfusion Through Motion Compensation in Fluorescence-Guided Surgery.Diagnostics (Basel, Switzerland) · 2026Article
- Deep impact analysis of surgical strategy changes guided by indocyanine green fluorescence angiography in laparoscopic low anterior resection for rectal cancer.International journal of colorectal disease · 2026Observational
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAnastomotic leak is a potentially life-threatening complication of colorectal surgery, with perfusion and height of anastomoses considered important risk factors. Indocyanine green (ICG) is commonly used in fluorescence angiography (FA) for perfusion assessment though techniques vary. This is a network meta-analysis comparing use of ICG-FA and height of anastomosis for left sided colorectal anastomoses and rates of anastomotic leak.
methodsA systematic review was performed including all adult clinical studies using ICG-FA in colorectal anastomoses. A network meta-analysis was performed to compare high and low anterior resections and the use of ICG for the outcome of anastomotic leak.
resultsOf some 333 studies retrieved during review, 31 studies were included, totalling 6431 patients. In a meta-analysis to compare high and low anterior resection, with and without ICG, odds of anastomotic leak were greater in low compared to high anastomoses, and ICG is protective in both, OR of 0.38 (0.20-0.73) for high and OR of 0.41 (0.30-0.54) in low anastomoses, with ICG compared to without.
conclusionThere is benefit of ICG for both HAR and LAR in reducing anastomotic leak. While there is no consensus on the application, dosage and timing of ICG during anterior resection, pooled results and most studies have shown that the use of ICG to check for tissue perfusion of anastomosis reduces leak. ICG should be considered as part of a surgeon's armamentarium for intraoperative anastomotic check to reduce the risk of postoperative anastomotic leak.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.