ArticleNature2025
SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Article
- Strong, sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility.Cell host & microbe · 2026Article
- CYTOKINE SIGNALING REGULATES MULTIPLE STAGES OF GAMMA-HERPESVIRUS INFECTION IN MYELOID CELLS.bioRxiv : the preprint server for biology · 2026Article
- Selective decay of interferon mRNAs controls antiviral immunity and innate memory.Molecular cell · 2026Article
- Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026Review
- IFN𝛾 and IFN𝛾 mimetics prevent IFN-I-mediated TB susceptibility by regulating iron metabolism and lipid peroxidation.bioRxiv : the preprint server for biology · 2026Article
- Article
- Transcriptomic and proteomic profiling of piroplasmosis resistance in Yunnan humped cattle.BMC genomics · 2026Article
- Single-cell profiling reveals that dynamic lung immune responses distinguish protection from susceptibility to tuberculosis.PLoS pathogens · 2026Article
- A Vertebrate Toxin-Antidote System That Sabotages Mouse Embryogenesis.bioRxiv : the preprint server for biology · 2026Article
- Oral Islatravir in Macaques Decreases Lymphocytes and Monocytes and Is Associated with Immune Alterations.Pharmaceutics · 2026Article
- Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response.Science (New York, N.Y.) · 2026Article
- Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility.bioRxiv : the preprint server for biology · 2026Article
- E3 ligase UHRF2 hijacks nuclear TBK1 to epigenetically repress type I interferons expression.International journal of biological sciences · 2026Article
- Host Genetic Architecture between Epstein-Barr Virus Activity and Multiple Sclerosis Reveals Shared Pathways.medRxiv : the preprint server for health sciences · 2025Article
- From Genetic Engineering to Preclinical Safety: A Study on Recombinant Human Interferons.International journal of molecular sciences · 2025Article
- The CCR4-NOT complex: a multifaceted sensor of molecular signals instructing eukaryotic mRNA translation and stability.Nucleic acids research · 2025Review
- Article
- Rewiring interferon fate: a bidirectional strategy for immune homeostasis.Signal transduction and targeted therapy · 2025Article
- Article
Corrections and comments
- Update of
Authors and funding
21 authors.
Kristen C WittHoward Hughes Medical Institute, University of California, Berkeley, CA, USA.
Adam DziulkoDepartment of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.
Joohyun AnDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.
Filip PekovicNational Cancer Institute, National Institutes of Health, Frederick, MD, USA.ORCID 0000-0001-6260-6452
Arthur Xiuyuan ChengDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.ORCID 0000-0002-3617-7268
Grace Y LiuHoward Hughes Medical Institute, University of California, Berkeley, CA, USA.ORCID 0000-0001-5463-3055
Ophelia Vosshall LeeDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.ORCID 0000-0002-3940-7807
David J TurnerNational Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Azra LariDepartment of Plant & Microbial Biology, University of California, Berkeley, CA, USA.ORCID 0000-0002-9649-8231
Moritz M GaidtDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.
Roberto ChavezHoward Hughes Medical Institute, University of California, Berkeley, CA, USA.
Stefan A FattingerDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.ORCID 0000-0003-4899-4414
Preethy AbrahamDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.
Harmandeep DhaliwalCancer Research Laboratory, University of California, Berkeley, CA, USA.
Angus Y LeeCancer Research Laboratory, University of California, Berkeley, CA, USA.
Dmitri I KotovDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.ORCID 0000-0001-7843-1503
Laurent CoscoyDivision of Immunology and Molecular Medicine, University of California, Berkeley, CA, USA.
Britt A GlaunsingerHoward Hughes Medical Institute, University of California, Berkeley, CA, USA.ORCID 0000-0003-0479-9377
Eugene ValkovNational Cancer Institute, National Institutes of Health, Frederick, MD, USA.ORCID 0000-0002-3721-1739
Edward B ChuongDepartment of Molecular, Cellular, and Developmental Biology and BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-5392-937X
Russell E VanceHoward Hughes Medical Institute, University of California, Berkeley, CA, USA. rvance@berkeley.edu.ORCID 0000-0002-6686-3912
Funding
The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI PORTNOY, DANIEL A · 2004 to 2025
$45.5MFunctional and Structural Dissection of Inflammasome ActivationR37AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RUSSELL E VANCE · 2018 to 2026
$3.8MSpecificity and in vivo function of the Naip/Nlrc4 inflammasomesR01AI075039 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI VANCE, RUSSELL E · 2008 to 2017
$3.6MDissection of Shigella pathogenesis in vivo using a new oral infection mouse modelR01AI155634 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI VANCE, RUSSELL E · 2020 to 2024
$2.2MNIAID NIH HHS P01 AI063302NIAID NIH HHS R01 AI075039NIAID NIH HHS R01 AI155634NIAID NIH HHS R37 AI075039
Abstract
Type I interferons are essential for antiviral immunity
Indexed as
Interferon-betaRNA StabilityAnimalsGammaherpesvirinaeHEK293 CellsHumansMiceRNA-Binding ProteinsRNA, MessengerTristetraprolinVirus ReplicationInterferon-betaRNA-Binding ProteinsRNA, MessengerTristetraprolin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.