Evidence map›Paper›PMID 40500445›Full record

ArticleNature2025

Dynamic assemblies and coordinated reactions of non-homologous end joining.

Lan Liu, Jun Li, Metztli Cisneros-Aguirre, Arianna Merkell, Jeremy M Stark, Martin Gellert, Wei Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Extrachromosomal DNA and cancer: function, formation, and clinical implications.Journal of experimental & clinical cancer research : CR · 2026
    Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lan Liu *Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1433-404X
Jun Li *Laboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA.
Metztli Cisneros-AguirreDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Arianna MerkellDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Jeremy M StarkDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0002-2625-5373
Martin GellertLaboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA. martinge@niddk.nih.gov.ORCID 0000-0002-0832-4929
Wei YangLaboratory of Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD, USA. weiy@niddk.nih.gov.ORCID 0000-0002-3591-2195

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Elucidating the role of DNAPKcs in chromosomal break end joining and clastogen resistanceR01CA256989 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI STARK, JEREMY MICHAEL · 2021 to 2025
$2.1M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA256989
6 · The paper itself

Abstract

Non-homologous end joining (NHEJ) is the main repair pathway of double-strand DNA breaks in higher eukaryotes

Indexed as

DNA-Directed DNA PolymeraseDNA End-Joining RepairDNA LigasesDNADNA-Activated Protein KinaseDNA-Binding ProteinsDNA Breaks, Double-StrandedDNA Ligase ATPDNA Repair EnzymesHumansKu AutoantigenModels, MolecularDNADNA-Activated Protein KinaseDNA-Binding ProteinsDNA-Directed DNA PolymeraseDNA Ligase ATPDNA LigasesDNA polymerase muDNA Repair EnzymesKu AutoantigenLIG4 protein, humanPAXX protein, humanXRCC4 protein, human

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.