ArticleNature2025
Early life high fructose impairs microglial phagocytosis and neurodevelopment.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- 3-Hydroxydehydroleucodin ameliorates neuroinflammation and ischemic brain injury by blocking the TRIM21-PRDX1 interaction.Acta pharmacologica Sinica · 2026Article
- Consumption of Fructose by Cultured Primary Rat Astrocytes.Neurochemical research · 2026Article
- Telmisartan Repurposing Targets Novel Biomarkers for Precision Colorectal Cancer Therapy.Pharmaceutics · 2026Article
- Sugar restriction during the first 1000 days after conception and its association with decreased risk of anxiety and depression.General psychiatry · 2026Article
- D-Fructose Exposure Impairs Neuronal Development in Mouse Neural Stem Cells.International journal of molecular sciences · 2026Article
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
- Reshaping the immune landscape: next-generation microglia-targeted therapies for Alzheimer's disease.Biological research · 2026Review
- Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis.Signal transduction and targeted therapy · 2026Article
- Genetic-Environmental Programming of Microglial Identity: Shaping Spatiotemporal Dynamics in Neurodevelopment and Neurodevelopmental Diseases.Cellular and molecular neurobiology · 2026Review
- ARHGAP39 plays an essential role in anxiety-like behavior and stress response.Translational psychiatry · 2026Article
- Fructose: metabolic signal and modern hazard.Nature metabolism · 2026Review
- Metabolic Reprogramming of Microglia in Neuroinflammation and Depression.International journal of molecular sciences · 2026Review
- LCN2/SLC22A17 mediates the phagocytosis of GABAergic synapses by oligodendrocyte progenitor cells and contributes to cancer-induced pain and comorbid anxiety-like behaviors in mice.Acta neuropathologica communications · 2026Article
- Microglial fructose metabolism is essential for glioblastoma growth.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Polystyrene microplastic-induced pathophysiology is driven by disruption of efferocytosis.Immunity · 2026Article
- Trump, Coca-Cola and the fructose frenzy that influences brain and neuronal tumor development.Cell death and differentiation · 2026Article
- Article
- Testosterone deficiency synergistically exacerbates fructose-induced hepatic steatosis through gut microbiota and pyruvate in mice.American journal of physiology. Endocrinology and metabolism · 2026Article
- Common metabolic, environmental, and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders.Frontiers in neurology · 2026Review
- Developmental origins of immunometabolic health.Immunometabolism (Cobham, Surrey) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Zhaoquan WangImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-8227-0941
Allie LipshutzImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-1786-7300
Celia Martínez de la TorreDepartment of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alissa J TrzeciakImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4518-0098
Zong-Lin LiuImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Isabella C MirandaDivision of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.
Tomi LazarovImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6312-0080
Ana C CodoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9036-5772
Jesús E Romero-PichardoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-4400-5765
Achuth NairImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tanya SchildDepartment of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Waleska Saitz RojasImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Pedro H V SaavedraImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-7659-4533
Ann K BaakoNeuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0009-0004-4112-1260
Kelvin FadojutimiImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael S DowneyImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-9818-5274
Frederic GeissmannImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5029-2468
Giuseppe FaracoFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Li GanHelen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-4600-275X
Jon Iker EtchegarayDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Christopher D LucasUniversity of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.ORCID 0000-0002-7523-0295
Marina TanasovaDepartment of Chemistry, Michigan Technological University, Houghton, MI, USA.
Christopher N ParkhurstDepartment of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Melody Y ZengImmunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-0031-4267
Kayvan R KeshariDepartment of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Justin S A PerryImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.ORCID 0000-0003-4063-6524
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MLeveraging fructose transport to create a privileged substrate to selectively fuel T cellsR01CA248364 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Kayvan R Keshari · 2021 to 2026
$4.3MIMMUNOLOGY RESEARCH TRAININGT32CA009149 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI RUDENSKY, ALEXANDER Y · 1985 to 2022
$4.0MRethinking the "quiet" nature of apoptotic cell clearance.DP2GM146337 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2021 to 2024
$2.6MMolecular Imaging in Cancer Biology Training ProgramT32CA254875 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Jason S. Lewis, Michael H. Overholtzer · 2021 to 2026
$2.1MRegulation of tumor-associated phagocyte physiology during tumor cell clearanceR00CA237728 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PERRY, JUSTIN S · 2019 to 2021
$747kImmunology and Microbial Pathogenesis Research Training ProgramT32AI134632 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI EHRT, SABINE, LI, MING · 2019 to 2023
$747kWNK1-dependent macropinocytosis mediates emergency myelopoiesisK99HL171844 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI TRZECIAK, ALISSA JANE · 2024 to 2025
$251kMedical Research Council MR/W019264/1Medical Research Council MR/X019314/1NCI NIH HHS P30 CA008748NCI NIH HHS R00 CA237728NCI NIH HHS R01 CA248364NCI NIH HHS T32 CA009149NCI NIH HHS T32 CA254875NHLBI NIH HHS K99 HL171844NIAID NIH HHS T32 AI134632NIGMS NIH HHS DP2 GM146337
Abstract
Despite the success of fructose as a low-cost food additive, epidemiological evidence suggests that high fructose consumption during pregnancy or adolescence is associated with disrupted neurodevelopment
Indexed as
FructoseMicrogliaPhagocytosisAnimalsAnimals, NewbornAnxietyFemaleGlucose Transporter Type 5HexokinaseHumansMaleMiceMitochondriaPregnancyFructoseGlucose Transporter Type 5HexokinaseSlc2a5 protein, mouse
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.