ArticleClinical oral investigations2025
The effect of conditioning regimen intensity on periodontal health in haematopoietic cell transplantation recipients: a 5-year multicentre prospective cohort study.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate periodontal health and its association with conditioning intensity over five years post-HCT. MATERIALS AND
methodsThis multicentre prospective study included 104 patients from two Dutch centres. Probing pocket depth (PPD), bleeding on probing (BOP), and buccal gingival recession (GR) were assessed pre-HCT and at three (n = 34), six (n = 45), twelve (n = 46), eighteen months (n = 30), and five years (n = 36) post-HCT. Regression models evaluated associations with conditioning intensity and time since HCT.
resultsHCT recipients had a median age of 58 years; 56% were male, and 59% received an allogeneic transplant. At baseline, mean PPD was 2.3 mm (31% had PPD ≥ 6 mm), mean BOP was 23%, and the median number of teeth with GR ≥ 1 mm was nine. Conditioning intensity was not significantly associated with PPD, GR, or BOP over time. Mean PPD decreased slightly at twelve months post-HCT (-0.21 mm (95%CI -0.28, -0.14)) but increased marginally at five years (0.12 mm (95%CI 0.08, 0.16)) compared to baseline. GR increased gradually with 0.13 mm (95%CI 0.07, 0.19) at twelve months, and 0.16 mm (95%CI 0.10, 0.23) at five years. BOP declined at twelve months (-11% (95%CI -15, -8)) but returned to baseline at five years (-1% (95%CI -5, 4)).
conclusionsOur results suggest that conditioning intensity does not affect long-term periodontal health. Periodontal changes up to five years post-HCT were small. CLINICAL RELEVANCE: Conditioning intensity may not be a key determinant of post-HCT periodontal health. Post-HCT periodontal deterioration was not found in our study.
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