ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025
Medial nucleus accumbens dopamine receptors modulate motivation for wheel running in male mice.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of ketamine on reward processing in depressive disorders: a systematic review of neuroimaging studies.CNS spectrums · 2026Pooled it
- Methods for measuring neural activity during voluntary wheel running.Journal of neuroscience methods · 2026Article
- Adenosine APsychopharmacology · 2026Article
- The GLP-1R Agonist Semaglutide Reduces Motivated Running and Alters Dopamine Dynamics in the Nucleus Accumbens.bioRxiv : the preprint server for biology · 2025Article
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Abstract
Abnormal motivation for natural rewards is a hallmark of various psychiatric disorders, including behavioral addiction. The mesolimbic dopamine pathway has been identified as a critical modulator of motivated behavior primarily based on studies using food-reinforced operant tasks. However, the focus on food rewards in previous studies limits the generalizability of these findings to other natural rewards implicated in behavioral addiction. In this study, we investigated the reinforcing and high motivational properties of wheel running in rodents by developing a wheel running-reinforced operant conditioning procedure. This procedure allowed for the independent quantification of appetitive and consummatory behaviors as operant responses and running duration, respectively, facilitating an in-depth exploration of the role of dopamine signaling in the medial nucleus accumbens (mNAc) in wheel running motivation. The results indicated that the systemic inhibition of dopamine D
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