Evidence map›Paper›PMID 40500386›Full record

ArticleNature metabolism2025

A food-sensitive olfactory circuit drives anticipatory satiety.

Janice Bulk, Joscha N Schmehr, Tobias Ackels, Rui de Oliveira Beleza, André Carvalho, Ayden Gouveia, Lionel Rigoux, Vincent Hellier, Anna Lena Cremer, Heiko Backes and 2 more

Abstract read
In one paragraph

Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Janice BulkMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Joscha N SchmehrMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Tobias AckelsSensory Circuits and Neurotechnology Lab, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-4964-1162
Rui de Oliveira BelezaMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
André CarvalhoMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Ayden GouveiaMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Lionel RigouxExcellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Vincent HellierMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Anna Lena CremerMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Heiko BackesMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany.
Andreas SchaeferSensory Circuits and Neurotechnology Lab, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-4677-8788
Sophie M SteculorumMax Planck Institute for Metabolism Research, Max Planck Research Group Neurocircuit Wiring and Function, Cologne, Germany. sophie.steculorum@sf.mpg.de.ORCID http://orcid.org/0000-0002-5665-2732

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food sensory perception has emerged as a potent regulator of specialized feeding circuits; yet, the consequences on feeding behaviour and the underlying neuronal basis remain poorly understood. Here, we reveal a sensory pathway that co-ordinately integrates food odours to control forthcoming nutrient intake in male mice. Unbiased whole-brain mapping of food odour-induced brain activity revealed a potent activation of the medial septum (MS), where food odours selectively activate MS glutamatergic neurons (MS

Indexed as

Olfactory PathwaysOlfactory PerceptionSatiationSatiety ResponseSmellAnimalsEatingFeeding BehaviorFoodMaleMiceMice, Inbred C57BLNeuronsOdorantsOlfactory BulbOptogenetics

Identifiers

PMID40500386
PMCPMC12198014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.