Evidence map›Paper›PMID 40500346›Full record

ArticleNPJ precision oncology2025

Genome-wide analyses identify circAQR, a circular RNA suppressing proliferation but promoting migration and invasion in thyroid cancer.

Tianjiao Zhou, Zheng Li, Weijun Huang, Enhui Zhou, Yumeng Jiang, Yueqing Bai, Chen Xu, Wen Lu, Kaiming Su, Chuan Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianjiao Zhou *Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zheng Li *Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200240, China.
Weijun Huang *Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Enhui ZhouDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yumeng JiangDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yueqing BaiDepartment of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen XuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wen LuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kaiming SuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chuan XuDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. chuanx@sjtu.edu.cn.
Hongliang YiDepartment of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. yihongl@126.com.

Funding

National Natural Science Foundation of China 32270704National Natural Science Foundation of China 82301311STI2030-Major Projects 2021ZD0201900the Fundamental Research Funds for the Central Universities YG2025QNB51
6 · The paper itself

Abstract

Thyroid cancer frequently metastasizes, even in small lesions, significantly impacting prognosis. Circular RNAs (circRNAs) have emerged as critical regulators of tumor biology; however, their roles in thyroid cancer progression remain poorly understood. Using RNA sequencing data from clinical and GEO-derived samples, we identified 111,971 circRNAs, including 13,399 novel thyroid cancer-specific circRNAs. TNM stage-specific analysis revealed 43 circRNAs positively correlated with tumor size (Rho = 1) and 168 negatively correlated (Rho = -1). Gene Ontology enrichment analysis demonstrated that the target genes of thyroid cancer-specific circRNAs are enriched in cell developmental regulation pathways (NES = 1.74, p < 0.05). Network analysis further suggested that these circRNAs function as competing endogenous RNAs by interacting with tumor-associated microRNAs. Among these, circAQR was significantly associated with tumor size and lymph node metastasis. In vitro experiments revealed that circAQR inhibits proliferation while promoting migration and invasion in thyroid cancer cell lines. These findings highlight the pivotal role of TNM stage-specific circRNAs in thyroid cancer progression, with circAQR showing potential as a biomarker for early metastasis detection and a therapeutic target. The integration of circRNAs into clinical practice could improve early diagnosis and prognostic evaluation, contributing to more effective management of thyroid cancer.

Identifiers

PMID40500346
PMCPMC12159170

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