ArticleNature neuroscience2025
A flexible hippocampal population code for experience relative to reward.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Goal-directed hippocampal theta sweeps during memory-guided navigation.Nature neuroscience · 2026Article
- Prefrontal-thalamic goal states organize spatially aligned hippocampal maps.Nature communications · 2026Article
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- Flexible navigation with neuromodulated cognitive maps.PLoS computational biology · 2026Article
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Entorhinal cortex represents task-relevant remote locations independently of CA1.Nature neuroscience · 2026Article
- Meta-learning is expressed through altered prefrontal cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Ketogenic Diet Promotes Reward Learning by Upregulating Hippocampal CAMK2A Expression and Activating Dopamine Synaptic Signaling.International journal of molecular sciences · 2026Article
- Divergent neural representations of space and task between physical and virtual navigation in macaques.Nature communications · 2026Article
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- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
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- Spaces and sequences in the hippocampus: a homological perspective.Journal of computational neuroscience · 2026Article
- Predictive coding of reward in the hippocampus.Nature · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Single-Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Facilitating analysis of open neurophysiology data on the DANDI Archive using large language model tools.Scientific data · 2025Article
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Abstract
To reinforce rewarding behaviors, events leading up to and following rewards must be remembered. Hippocampal place cell activity spans spatial and non-spatial episodes, but whether hippocampal activity encodes entire sequences of events relative to reward is unknown. Here, to test this possibility, we performed two-photon imaging of hippocampal CA1 as mice navigated virtual environments with changing hidden reward locations. We found that when the reward moved, a subpopulation of neurons updated their firing fields to the same relative position with respect to reward, constructing behavioral timescale sequences spanning the entire task. Over learning, this reward-relative representation became more robust as additional neurons were recruited, and changes in reward-relative firing often preceded behavioral adaptations following reward relocation. Concurrently, the spatial environment code was maintained through a parallel, dynamic subpopulation rather than through dedicated cell classes. These findings reveal how hippocampal ensembles flexibly encode multiple aspects of experience while amplifying behaviorally relevant information.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.