Evidence map›Paper›PMID 40500270›Full record

ArticleNature communications2025

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma.

Fernando T Zamuner, Sreenivasulu Gunti, Gabriel J Starrett, Farhoud Faraji, Tiffany Toni, Anirudh Saraswathula, Kenny Vu, Anuj Gupta, Yan Zhang, Daniel L Faden and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Fernando T Zamuner *Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6106-4361
Sreenivasulu Gunti *Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Gabriel J Starrett *Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Farhoud FarajiDepartment of Otolaryngology - Head and Neck Surgery and Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-5078-813X
Tiffany ToniDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anirudh SaraswathulaDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kenny VuSinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9396-1120
Anuj GuptaSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Yan ZhangSidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Daniel L FadenDepartment of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.
Michael E BryanDepartment of Otolaryngology - Head and Neck Surgery, Harvard Medical School, Boston, MA, USA.
Theresa GuoDepartment of Otolaryngology - Head and Neck Surgery and Moores Cancer Center, University of California San Diego Health, La Jolla, CA, USA.
Nicholas R RowanDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1296-2648
Murugappan RamanathanDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrew P LaneDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-6369-5469
Carole FakhryDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gary L GalliaDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Clint T AllenHead and Neck Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6586-5804
Lisa M RooperDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nyall R LondonDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. nyall.london@nih.gov.ORCID http://orcid.org/0000-0002-2902-4407

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
NCATS NIH HHS KL2 TR001444
6 · The paper itself

Abstract

Mechanisms of tumorigenesis in sinonasal squamous cell carcinoma (SNSCC) remain poorly understood due to its rarity. A subset of SNSCC is associated with human papillomavirus (HPV), but it is unclear whether HPV drives tumorigenesis or acts as a neutral bystander. Here, we show that HPV-associated SNSCC shares mutational patterns found in HPV-associated cervical and head and neck squamous cell carcinoma, including lack of TP53 mutations, hotspot mutations in PI3K and FGFR3, enrichment of APOBEC mutagenesis, viral integration at known hotspots, and frequent epigenetic regulator alterations. We identify HPV-associated SNSCC-specific recurrent mutations in KMT2C, UBXN11, AP3S1, MT-ND4, and MT-ND5, with KMT2D and FGFR3 mutations correlating with reduced overall survival. We establish an HPV-associated SNSCC cell line, showing that combinatorial small-molecule inhibition of YAP/TAZ and PI3K synergistically suppresses clonogenicity. Combining YAP/TAZ blockade with vertical PI3K inhibition may benefit HPV-associated SNSCC, whereas targeting MYC and horizontal inhibition of RAS/PI3K may suit HPV-independent SNSCC.

Indexed as

CarcinogenesisCarcinoma, Squamous CellPapillomaviridaePapillomavirus InfectionsParanasal Sinus NeoplasmsAdaptor Proteins, Signal TransducingCell Line, TumorDNA-Binding ProteinsFemaleHumansMutationNeoplasm ProteinsPhosphatidylinositol 3-KinasesReceptor, Fibroblast Growth Factor, Type 3Squamous Cell Carcinoma of Head and NeckTranscription FactorsAdaptor Proteins, Signal TransducingDNA-Binding ProteinsFGFR3 protein, humanKMT2D protein, humanNeoplasm ProteinsPhosphatidylinositol 3-KinasesReceptor, Fibroblast Growth Factor, Type 3Transcription FactorsTumor Suppressor Protein p53

Identifiers

PMID40500270
PMCPMC12159145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.