Evidence map›Paper›PMID 40500180›Full record

ArticleThe Journal of veterinary medical science2025

Surveillance of amyloid A deposits in commercial beef liver and assessment of food hygiene risks.

Susumu Iwaide, Natsumi Kobayashi, Kenta Owaku, Niki Sedghi Masoud, Naoki Ujike, Yoshiyuki Itoh, Takuma Kozono, Miki Hisada, Kumiko Kimura, Tomoyuki Shibahara and 1 more

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Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Susumu IwaideNational Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan.
Natsumi KobayashiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Kenta OwakuLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Niki Sedghi MasoudLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Naoki UjikeLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Yoshiyuki ItohSmart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Takuma KozonoSmart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Miki HisadaSmart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Kumiko KimuraNational Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan.
Tomoyuki ShibaharaNational Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan.
Tomoaki MurakamiLaboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine amyloid A (AA) amyloidosis has been reported to be experimentally transmitted to mice, like prion disease. Although the prevalence of AA amyloidosis in cattle at slaughterhouses has been reported in several studies, how much bovine AA is distributed in retail stores remains unknown. In this study, to clarify the food hygienic risk of bovine AA, we collected beef livers from seven commercial retail stores in Japan to investigate the deposition rate and the transmissibility of bovine AA. Congo red staining and immunohistochemistry revealed bovine AA deposition in two of 185 commercial beef livers (1.08%). No differences were observed between the gross appearance of amyloid-laden and amyloid-free livers. Administration of bovine AA from commercial beef liver to mice, either intraperitoneally or into the spleen, did not promote the development of AA amyloidosis. This contrasts with previous studies demonstrating cross-species transmission of AA amyloidosis via intraperitoneal or even oral administration of bovine AA. Although the cause of this discrepancy is unknown, the low transmissibility may be related to the species-barrier. These results support that the actual food hygienic risk of AA amyloidosis associated with consuming commercial beef liver may not be significant.

Indexed as

AmyloidosisFood SafetyLiverRed MeatSerum Amyloid A ProteinAmyloidAnimal HusbandryAnimalsCattleEpidemiological MonitoringFood HandlingJapanMiceMice, Inbred C57BLMicroscopy, Electron, TransmissionAmyloidSerum Amyloid A Proteinamyloid A amyloidosiscattlecross-species transmissionfood hygieneliver

Identifiers

PMID40500180
PMCPMC12344302

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.