ArticleThe Journal of veterinary medical science2025
Participation of autophagy in D-galactosamine-induced acute rat liver injury.
Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Autophagy is an intracellular degradation system that generates autophagosomes. Autophagy was investigated in rat hepatic lesions induced by a single intraperitoneal injection of D-galactosamine (D-GalN) that can induce hepatic lesions mimicking human viral hepatitis. Lesions consisting of hepatocyte necrosis were sporadically seen within hepatic lobules on post-injection days 1 and 2, and recovered on days 3 and 5. The number of LC3B-immunopositive cytoplasmic granules (autophagosomes) increased significantly in hepatocytes on days 1 and 2 with increased Toll-like Receptor-2 (TLR-2) mRNA. Interestingly, there were some abnormal autophagosomes with vacuolated or irregular structures, being related to decreased mRNA level of Lamp2 at 8 hr and on days 2-5. These results indicated that autophagy may participate in the development of D-GalN-induced rat acute liver lesions through its activation or degradation.
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