Evidence map›Paper›PMID 40500161›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Association between Myasthenia Gravis and Smoking.

Hiroyuki Akamine, Akiyuki Uzawa, Satoshi Kuwabara, Shigeaki Suzuki, Yosuke Onishi, Manato Yasuda, Yukiko Ozawa, Naoki Kawaguchi, Tomoya Kubota, Masanori P Takahashi and 10 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Hiroyuki AkamineDepartment of Neurology, Graduate School of Medicine, Chiba University, Japan.
Akiyuki UzawaDepartment of Neurology, Graduate School of Medicine, Chiba University, Japan.
Satoshi KuwabaraDepartment of Neurology, Graduate School of Medicine, Chiba University, Japan.
Shigeaki SuzukiDepartment of Neurology, Keio University School of Medicine, Japan.
Yosuke OnishiDepartment of Neurology, Graduate School of Medicine, Chiba University, Japan.
Manato YasudaDepartment of Neurology, Graduate School of Medicine, Chiba University, Japan.
Yukiko OzawaDepartment of Neurology, Graduate School of Medicine, Chiba University, Japan.
Naoki KawaguchiDepartment of Neurology, Neurology Chiba Clinic, Japan.
Tomoya KubotaDepartment of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, The University of Osaka Graduate School of Medicine, Japan.
Masanori P TakahashiDepartment of Clinical Laboratory and Biomedical Sciences, Division of Health Sciences, The University of Osaka Graduate School of Medicine, Japan.
Yasushi SuzukiDepartment of Neurology, National Hospital Organization Sendai Medical Center, Japan.
Genya WatanabeDepartment of Neurology, National Hospital Organization Sendai Medical Center, Japan.
Takashi KimuraDepartment of Neurology, Hyogo Medical University, Japan.
Takamichi SugimotoDepartment of Clinical Neuroscience and Therapeutics, Hiroshima University, Japan.
Makoto SamukawaDepartment of Neurology, Kindai University Faculty of Medicine, Japan.
Naoya MinamiDepartment of Neurology, National Hospital Organization Hokkaido Medical Center, Japan.
Masayuki MasudaDepartment of Neurology, Tokyo Medical University, Japan.
Shingo KonnoDepartment of Neurology, Toho University Ohashi Medical Center, Japan.
Yuriko NaganeDepartment of Neurology, Hanamaki General Hospital, Japan.
Kimiaki UtsugisawaDepartment of Neurology, Hanamaki General Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective This study investigated the association between smoking and myasthenia gravis (MG), a chronic autoimmune disorder that affects neuromuscular junctions. Methods Data were collected from the Japan MG Registry 2021 survey conducted between April and October 2021. MG severity was assessed using the MG activities of daily living score and MG Foundation of America (MGFA) classification. The Brinkman Index, calculated as the number of cigarettes smoked per day multiplied by the number of years smoked, was used to evaluate the correlation between smoking exposure and MG severity. We also compared the smoking rates of individuals with and without MG stratified by age and sex. Results Of the 1,402 patients selected from the Japanese registry, higher smoking rates were observed in patients with MG than in the general population. Compared with never-smokers, women with MG who smoked were younger and had a higher prevalence of ocular symptoms. A weak correlation was observed between MGFA and Brinkman indices among men with MG who smoked. No correlation was observed between smoking status and MG severity in women who smoked. Conclusion This study utilized one of the largest datasets on MG and smoking; thus, it provides valuable insights into the association between smoking and MG.

Indexed as

Myasthenia GravisSmokingActivities of Daily LivingAdultAgedFemaleHumansJapanMaleMiddle AgedPrevalenceRegistriesSeverity of Illness IndexSex Factorsautoimmune disordermyasthenia gravissmoking

Identifiers

PMID40500161
PMCPMC12804487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.