Evidence map›Paper›PMID 40500149›Full record

ArticleRNA (New York, N.Y.)2025

Structural analysis of the lncRNA SChLAP1 reveals protein binding interfaces and a conformationally heterogenous retroviral insertion.

James P Falese, Emily J McFadden, Christopher A D'Inzeo, Amanda E Hargrove

Abstract read
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. ChemBioParis 2025: Approaching Biology Through Chemistry in the City of Light.Chembiochem : a European journal of chemical biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

James P FaleseDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.ORCID 0000-0002-5481-3096
Emily J McFaddenDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.ORCID 0000-0003-1873-0557
Christopher A D'InzeoDepartment of Chemistry, Duke University, Durham, North Carolina 27708, USA.ORCID 0009-0003-5410-4817
Amanda E HargroveDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA amanda.hargrove@utoronto.ca.ORCID 0000-0003-1536-6753

Funding

University Training Program in Biomolecular & Tissue EngineeringT32GM008555 · NIGMS · DUKE UNIVERSITY · PI GERSBACH, CHARLES A. · 1994 to 2021
$8.1M
Therapeutic Targeting of The Long Noncoding RNA SCHLAP1 in Aggressive Prostate CancerR21CA277305 · NCI · DUKE UNIVERSITY · PI HARGROVE, AMANDA E, SOMARELLI, JASON ANDREW · 2023 to 2024
$394k
NCI NIH HHS R21 CA277305NIGMS NIH HHS T32 GM008555
6 · The paper itself

Abstract

The lncRNA second chromosome locus associated with prostate 1 (SChLAP1) was previously identified as a predictive biomarker and potential driver of aggressive prostate cancer. Recent work suggested that SChLAP1 may bind the SWI/SNF chromatin remodeling complex to promote prostate cancer metastasis, though the exact role of SWI/SNF recognition is debated. To date, there are no detailed biochemical studies of

Indexed as

RetroviridaeRNA, Long NoncodingAnimalsBinding SitesHumansMaleModels, MolecularNucleic Acid ConformationPhylogenyProstatic NeoplasmsProtein BindingRNA, Long Noncodinglong terminal repeatprostate cancerRNA structureSChLAP1SHAPE-MaP

Identifiers

PMID40500149
PMCPMC12360211

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.