ArticleThe Journal of nutrition2025
Dietary Supplement Use Is Associated with Select Serum Nutrient Biomarkers among Postmenopausal Women: Results from a Controlled Feeding Study.
Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000611 (Women's Health Initiative), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Women's Health Initiative (WHI)
Who cites it
1 citing paper in PubMed.
- Biomarkers for dietary fatty acid densities among postmenopausal United States females derived using a habitual-diet human feeding study.The American journal of clinical nutrition · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundDietary supplement use is common among older adults; however, the association between supplement use and corresponding nutrient biomarkers in this population is less well understood.
objectivesThis study aimed to determine whether older women using dietary supplements had higher serum concentrations of corresponding biomarkers and whether those using multiple supplement sources of the nutrient had incrementally higher serum nutrient concentrations.
methodsParticipants from the Women's Health Initiative enrolled in a 2-wk feeding study (n = 153). Women consumed an individualized menu and maintained intake of usual dietary supplements. Serum vitamin B12, lutein + zeaxanthin, and phospholipid fatty acids were measured at the end of the feeding period. Multiple linear regression of dietary supplement use, and participant characteristics on log-transformed serum biomarker concentrations was used to evaluate the association. One-way analysis of variance determined whether there were significant differences in mean serum biomarkers among participants based on the number of sources of a nutrient consumed via dietary supplement.
resultsIn multiple linear regression models (n = 152), users of vitamin B12 supplements had 58% higher geometric mean serum concentrations of vitamin B12 than nonusers (P < 0.001). Users of omega-3 fatty acid dietary supplements had geometric mean serum phospholipid docosahexaenoic acid + eicosapentaenoic acid that were 38%-46% higher than nonusers (P < 0.0001). In contrast, use of lutein + zeaxanthin-containing supplements was not associated with serum lutein + zeaxanthin (P = 0.72). Users of 2 sources of vitamin B12 and lutein + zeaxanthin-containing dietary supplements had higher corresponding serum biomarkers than users of only a multivitamin and users of neither (P < 0.0001).
conclusionsThe use of vitamin B12 and omega-3 fatty acid supplements were associated with higher serum biomarkers, respectively. Dietary supplements containing lutein + zeaxanthin may not increase serum biomarkers among postmenopausal women. TRIAL REGISTRATION NUMBER: This trial was registered at clinicaltrials.gov as NCT00000611.
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