ArticleCell2025
The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids.
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Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Article
- Mass spectrometry-based metabolomics approaches to interrogate host-microbiome interactions in mammalian systems.Natural product reports · 2026Review
- From Molecules to Metabolomes, Understanding Symbiosis through Small Molecules.Journal of natural products · 2026Review
- Serum metabolic signatures of cognitive resilience in a longitudinal aging cohort.bioRxiv : the preprint server for biology · 2026Article
- Antibiotic Exposure Through Human Milk Influences the Infant Gut Microbiome.bioRxiv : the preprint server for biology · 2026Article
- Pan-Metabolomics Repository Mapping of the Carnitine Landscape.bioRxiv : the preprint server for biology · 2026Article
- ProbioticVeterinary sciences · 2026Article
- Navigating the conjugated metabolome.bioRxiv : the preprint server for biology · 2026Article
- Community Curation of Microbial Metabolites Enables Biological Insights of Metabolomics Data.bioRxiv : the preprint server for biology · 2026Article
- Multiple Spectrum Alignment for Molecular Networking Exploration and Discovery.Journal of the American Society for Mass Spectrometry · 2026Article
- Microbiota and lipid mediators: from molecular crosstalk to therapeutic opportunities.Frontiers in pharmacology · 2026Review
- Effect of perinatal ampicillin or amoxicillin/clavulanate exposure on maternal and infant gut microbiome, metabolome, and infant responses to the 20-valent pneumococcal conjugate vaccine.Gut microbes reports · 2026Article
- From gut to lung: Microbiota-derived metabolites reshaping the tumor immune microenvironment.EXCLI journal · 2026Article
- Recent advances in the positive role ofFrontiers in immunology · 2026Review
- Fecal microbial and metabolic signatures in children with very early onset inflammatory bowel disease.NPJ biofilms and microbiomes · 2025Article
- Review
- Environmental and maternal imprints on infant gut metabolic development.Cell host & microbe · 2025Article
- A resource to empirically establish drug exposure records directly from untargeted metabolomics data.Nature communications · 2025Article
- Effect of Perinatal Ampicillin or Amoxicillin/Clavulanate Exposure on Maternal and Infant Gut Microbiome, Metabolome, and Infant Responses to the 20-valent Pneumococcal Conjugate Vaccine.bioRxiv : the preprint server for biology · 2025Article
- Emerging strategies to enhance microbial natural product-based drug discovery.Current opinion in biotechnology · 2025Review
Corrections and comments
- Update of
Authors and funding
48 authors.
Helena Mannochio-RussoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Vincent Charron-LamoureuxSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Martijn van FaassenSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, the Netherlands.
Santosh LamichhaneSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Institute of Biomedicine, Faculty of Medicine, University of Turku & Turku Bioscience Center, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Wilhan D Gonçalves NunesSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Victoria DeleraySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Adriana V AyalaDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Yuichiro TanakaDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Abubaker PatanSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Kyle VittaliSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Prajit RajkumarSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Yasin El AbieadSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Haoqi Nina ZhaoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Paulo Wender Portal GomesSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Ipsita MohantySkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Carlynda LeeSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Aidan SundSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Meera SharmaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Yuanhao LiuSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
David PattynamaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Gregory T WalkerDivision of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Grant J NortonDivision of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Lora KhatibDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Neurosciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Mohammadsobhan S AndalibiDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.
Crystal X WangDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.
Ronald J EllisDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.
David J MooreDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.
Jennifer E IudicelloDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.
Donald FranklinDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; HIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA.
Scott LetendreHIV Neurobehavioral Research Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Loryn ChinDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
Corinn WalkerDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.
Simone RenwickDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE) and the Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA 92093, USA.
Jasmine ZemlinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
Michael J MeehanSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Xinyang SongDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
Dennis KasperDepartment of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Zachary BurchamDepartment of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Jane J KimDepartment of Pediatrics, Division of Pediatric Endocrinology, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital San Diego, San Diego, CA 92123, USA.
Sejal KadakiaDivision of Pediatric Endocrinology, Children's Hospital of Orange County, Orange, CA 92868, USA.
Manuela RaffatelluDivision of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Chiba University - UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines, La Jolla, CA 92093, USA.
Lars BodeDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE) and the Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA 92093, USA.
Hiutung ChuDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Chiba University - UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines, La Jolla, CA 92093, USA.
Karsten ZenglerDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA.
Mingxun WangDepartment of Computer Science and Engineering, University of California, Riverside, Riverside, CA 92521, USA.
Dionicio SiegelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Rob KnightDepartment of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA 92093, USA; Shu Chien-Gene Lay Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA 92093, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: pdorrestein@health.ucsd.edu.
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MSTRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jessica Lynette Montoya · 2001 to 2026
$50.4MThe impact of ampicillin and breast milk oligosaccharides on the infant microbiome and immune functionsP50HD106463 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lars Bode, CHRISTINA CHAMBERS · 2021 to 2026
$19.6MRESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2MCollaborative Microbial Metabolite CenterU24DK133658 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2022 to 2026
$2.9MReverse Metabolomics for the Discovery of Disease Associated Microbial MoleculesR01DK136117 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2023 to 2026
$2.9MNutritional immunity during Salmonella infectionR37AI126277 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Manuela Raffatellu · 2023 to 2026
$1.8MA Genomic Approach to Discovering Novel Cathepsin Inhibitors from CyanobacteriaF32AT011475 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AVALON, NICOLE ELIZABETH · 2022 to 2024
$218kMetatranslatomics enables functional profiling of microbial competition in the Salmonella-perturbed gutF31AI186410 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NORTON, GRANT J · 2024 to 2025
$85kNCATS NIH HHS UL1 TR001442NCCIH NIH HHS F32 AT011475NIAID NIH HHS F31 AI186410NIAID NIH HHS R37 AI126277NIAID NIH HHS T32 AI007036NICHD NIH HHS P50 HD106463NIDDK NIH HHS R01 DK136117NIDDK NIH HHS U24 DK133658NIMH NIH HHS P30 MH062512
Abstract
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spectral library retrieving N-acyl lipid patterns from 2,700 public datasets, identifying 851 N-acyl lipids that were detected 356,542 times. 777 are not documented in lipid structural databases, with 18% of these derived from short-chain fatty acids and found in the digestive tract and other organs. Their levels varied with diet and microbial colonization and in people living with diabetes. We used the library to link microbial N-acyl lipids, including histamine and polyamine conjugates, to HIV status and cognitive impairment. This resource will enhance the annotation of these compounds in future studies to further the understanding of their roles in health and disease and to highlight the value of large-scale untargeted metabolomics data for metabolite discovery.
Indexed as
Fatty AcidsFatty Acids, VolatileLipidsMicrobiotaFemaleGastrointestinal MicrobiomeHumansMaleMass SpectrometryMetabolomicsFatty AcidsFatty Acids, VolatileLipidsHIVMassQLMASSTmetabolomics data miningmicrobialN-acyl lipidsneurocognitive impairmentrepository-scale analysisSCFAshort-chain fatty acids
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