Evidence map›Paper›PMID 40499529›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Olfactomedin-4 elevation in pediatric acute respiratory distress syndrome.

Ryan O'Sullivan, Matthew N Alder, Celeste G Dixon, Donglan Zhang, Nishi Srivastava, Nadir Yehya

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan O'SullivanDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Matthew N AlderDepartment of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States.
Celeste G DixonDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0003-1175-2235
Donglan ZhangDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Nishi SrivastavaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.
Nadir YehyaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.ORCID 0000-0002-2996-217X

Funding

Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress SyndromeR01HL148054 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI YEHYA, NADIR · 2019 to 2023
$4.1M
Clinical and Proteomic Characterization of Nucleosomes in Pediatric Acute Respiratory Distress SyndromeK23HL136688 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI YEHYA, NADIR · 2017 to 2020
$694k
HHS | National Institutes of Health (NIH) R01-HL148054NHLBI NIH HHS K23 HL136688NHLBI NIH HHS R01 HL148054
6 · The paper itself

Abstract

Neutrophils play a key role in acute respiratory distress syndrome (ARDS). The neutrophil marker olfactomedin-4 (OLFM4) has been implicated with worse outcomes in pediatric sepsis; however, OLFM4 has not been studied in pediatric ARDS. Therefore, we performed a secondary analysis of a prospective cohort of children with Berlin-defined ARDS with plasma collected on

Indexed as

Granulocyte Colony-Stimulating FactorRespiratory Distress SyndromeAdolescentBiomarkersChildChild, PreschoolFemaleHistonesHumansInfantLipopolysaccharidesMaleNeutrophilsProspective StudiesBiomarkersGranulocyte Colony-Stimulating FactorHistonesLipopolysaccharidesOLFM4 protein, humanARDSbiomarkersneutrophilsPARDS

Identifiers

PMID40499529
PMCPMC12213118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.